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Alzheimer's dementia by circulation disorders: when trees hide the forest

Nature Cell Biology volume 11, pages 114–116 (2009)Cite this article

Deposition of amyloid β-peptide in cerebral vessel walls, termed cerebral amyloid angiopathy (CAA), enhances the cognitive deficits associated with Alzheimer's disease. The molecular details by which circulatory defects with hypoxia alter peptide clearance, contributing to brain deposition and AD, are beginning to be elucidated.

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Figure 1: Neurovascular unit and a possible path to VSMC-mediated CAA and AD.

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Authors and Affiliations

  1. Carlos G. Dotti and Bart De Strooper are in the VIB Department of Molecular and Developmental Genetics (VIB11) and Center for Human Genetics, Katholieke Universiteit Herestraat 49, PO Box 603 3000, Leuven, Leuven, Belgium. Carlos.Dotti@med.kuleuven.be,

    Carlos G. Dotti & Bart De Strooper

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  1. Carlos G. Dotti
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  2. Bart De Strooper
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Dotti, C., Strooper, B. Alzheimer's dementia by circulation disorders: when trees hide the forest. Nat Cell Biol 11, 114–116 (2009). https://doi.org/10.1038/ncb0209-114

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