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Cytokinesis: mind the GAP

Cytokinesis ensures proper partitioning of genomic and cytoplasmic material between dividing cells. A key regulator of this process is the centralspindlin complex. Two recent papers report that GAP activity of one of the members of this complex regulates the function of Rho family GTPases during cytokinesis.

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Figure 1: The role of the RacGAP component of the centralspindlin complex in regulating the activity of Rho family GTPases during cytokinesis.

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D'Avino, P., Glover, D. Cytokinesis: mind the GAP. Nat Cell Biol 11, 112–114 (2009). https://doi.org/10.1038/ncb0209-112

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