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Keeping cartographers busy

In the post-genome era, there is increasing interest in developing quantitative models of cell function at the molecular level. Although data describing the role of individual proteins in cell behaviour remain rate-limiting for such efforts, large-scale screening approaches are providing results that can be used to map the protein–protein interactions of a living biological system.

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Figure 1: Tagged versions of known and predicted signalling pathway components (blue) are stably expressed at levels similar to those of the endogenous protein.

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Hayden, M., Ghosh, S. Keeping cartographers busy. Nat Cell Biol 6, 87–89 (2004). https://doi.org/10.1038/ncb0204-87

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