It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential.
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Lloyd, A. Limits to lifespan. Nat Cell Biol 4, E25–E27 (2002). https://doi.org/10.1038/ncb0202-e25
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DOI: https://doi.org/10.1038/ncb0202-e25
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