Abstract
Many classical biologists working in Antarctica have 'gone molecular' to study the physiological basis for life on or below the ice. Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional experimental organisms.
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References
Baker, D., Hicke, L., Rexach, M., Schleyer, M. & Schekman, R. Cell 54, 335–344 (1988).
Russell, N. J. Extremophiles 4, 83–90 (2000).
Gianese, G., Argos, P. & Pascarella, S. Protein Eng. 14, 141–148 (2001).
Fields, P. A. & Somero, G. N. Proc. Natl Acad. Sci. USA 95, 11476–11481 (1998).
Cheng, C. H. Curr. Opin Genet. Dev. 8, 715–720 (1998).
deVries, A. L. Comp. Biochem. Physiol. B 90, 611–621 (1988).
Harding, M. M., Ward, L. G. & Haymet, A. D. Eur. J. Biochem. 264, 653–665 (1999).
Chen, L., DeVries, A. L. & Cheng, C. H. Proc. Natl Acad. Sci. USA 94, 3811–3816 (1997).
Chen, L., DeVries, A. L. & Cheng, C. H. Proc. Natl Acad. Sci. USA 94, 3817–3822 (1997).
Verdier, J. M., Ewart, K. V., Griffith, M. & Hew, C. L. Eur. J. Biochem. 241, 740–743 (1996).
Graether, S. P. et al. J. Biol. Chem. 274, 11842–11847 (1999).
Antson, A. A. et al. J. Mol. Biol. 305, 875–889 (2001).
Leinala, E. K., Davies, P. L. & Jia, Z. Structure 10, 619–627 (2002).
Wu, Y. & Fletcher, G. L. Biochim. Biophys. Acta 1524, 11–16 (2001).
Tomczak, M. M. et al. Biophys. J. 82, 874–881 (2002).
Hunt, B. M., Hoefling, K. & Cheng, C. H. Antarctic Sci. (in the press).
Hofmann, G. E., Buckley, B. A., Airaksinen, S., Keen, J. E. & Somero, G. N. J. Exp Biol. 203, 2331–2339 (2000).
Rudiger, S., Buchberger, A. & Bukß, B. Nature Struct. Biol. 4, 342–349 (1997).
Somero, G. N. & deVries, A. L. Science 156, 257–258 (1967).
Eastman, J. T. in Antarctic Fish Biology, 220–243 (Academic Press, San Diego, 1993).
Hemmingsen, E. A. in Biology of Antarctic Fish (eds di Prisco, G., Maresca, B. & Tota, B.) 101–203 (Springer, Berlin, 1991).
Egginton, S., Skilbeck, C., Hoofd, L., Calvo, J. & Johnston, I. A. J. Exp. Biol. 205, 769–779 (2002).
Bargelloni, L., Marcato, S. & Patarnello, T. Proc. Natl Acad. Sci. USA 95, 8670–8675 (1998).
Portner, H. O. J. Exp. Biol. 205, 2217–2230 (2002).
Ruud, J. T. Nature 173, 848 (1954).
Cocca, E. et al. Proc. Natl Acad. Sci. USA 92, 1817–1821 (1995).
Johnston, I. I., Calvo, J. & Guderley, Y. H. J. Exp. Biol. 201, 1–12 (1998).
O'Brien, K. M. & Sidell, B. D. J. Exp. Biol. 203, 1287–1297 (2000).
Chapelle, G. & Peck, L. S. Nature 399, 114–115 (1999).
Dudley, R. Annu. Rev. Physiol. 62, 135–155 (2000).
Macdonald, J. A., Montgomery, J. C. & Wells, R. M. G. Adv. Marine Biol. 24, 321–388 (1987).
Carpenter, E. J., Lin, S. & Capone, D. G. Appl. Environ. Microbiol. 66, 4514–4517 (2000).
Arnold, F. H., Wintrode, P. L., Miyazaki, K. & Gershenson, A. Trends Biochem. Sci. 26, 100–106 (2001).
Schroder Leiros, H. K., Willassen, N. P. & Smalas, A. O. Eur. J. Biochem. 267, 1039–1049 (2000).
Petrescu, I. et al. Extremophiles 4, 137–144 (2000).
Detrich, H. W. 3rd, Parker, S. K., Williams, R. C. Jr., Nogales, E. & Downing, K. H. J. Biol. Chem. 275, 37038–37047 (2000).
Carminati, J. L. & Stearns, T. J. Cell Biol. 138, 629–641 (1997).
Marsh, A. G., Maxson, R. E. Jr. & Manahan, D. T. Science 291, 1950–1952 (2001).
Acknowledgements
We thank S. Munro, G. Schiavo, D. Ng, N. Collie, J.-C. Roeper, J. Young, J. Rosenthal and M. Gebhardt for critically reading the manuscript, and A. Stuart and M. Lindsay for the electron micrograph. K.R. was funded by a Wellcome Trust Senior Fellowship (042216). Work in T.M.'s lab was funded by the Biotechnology and Biological Sciences Research Council. We thank the National Science Foundation and British Antarctic Survey for supporting our research.
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Römisch, K., Matheson, T. Cell biology in the Antarctic: studying life in the freezer. Nat Cell Biol 5, 3–6 (2003). https://doi.org/10.1038/ncb0103-3
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DOI: https://doi.org/10.1038/ncb0103-3