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Capturing a ring of samurai

Abstract

The microtubule-severing protein katanin, an AAA protein, forms transient oligomers in the presence of ATP and microtubules, the latter of which act as a template for oligomer formation. AAA proteins in general may form transient oligomers on a protein-substrate template.

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Figure 1: Katanin forms oligomers only in the presence of microtubules and a slowly hydrolysable ATP analogue.
Figure 2: Katanin, VPS4 and NSF represent slight variations on a theme.

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McNally, F. Capturing a ring of samurai. Nat Cell Biol 2, E4–E6 (2000). https://doi.org/10.1038/71385

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