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Superfamily Structure and Biotech Drug Development

Bio/Technology volume 10, pages 1529–1534 (1992)Cite this article

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References

  1. Lowman, H., Cunningham, B., and Wells, J. 1991. Mutational analysis and protein engineering of receptor-binding determinants in human placental lactogen. J. Biol. Chem. 266: 10982–10988.

    CAS  PubMed  Google Scholar 

  2. Cunningham, B., Jhurani, P., Ng, P., and Wells, J. 1989. Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis. Science 243: 1330–1337.

    Article  CAS  Google Scholar 

  3. Cunningham, B., and Wells, J. 1989. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science 244: 1081–1085.

    Article  CAS  Google Scholar 

  4. Bass, S., Mulkerrin, M., and Wells, J. 1991. A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor. Proc. Natl. Acad. Sci. U.S.A. 88: 4498–4502.

    Article  CAS  Google Scholar 

  5. Cunningham, B., Henner, D., and Wells, J. 1990. Engineering human prolactin to bind to the human growth hormone receptor. Science 247: 1461–1465.

    Article  CAS  Google Scholar 

  6. Bass, S., Greene, R., and Wells, J. 1990. Hormone phage: an enrichment method for variant proteins with altered binding properties. Proteins: Structure, Function, and Genetics 8: 309–314.

    Article  CAS  Google Scholar 

  7. Lowman, H., Bass, S., Simpson, N., and Wells, J. 1991. Selecting high-affinity binding proteins by monovalent phage display. Biochemistry 30: 10832–10838.

    Article  CAS  Google Scholar 

  8. de Vos, A., Ultsch, M., and Kossiakoff, A. 1992. Human growth hormone and extracellular domain of its receptor: crystal Structure of the complex. Science 255: 306–312.

    Article  CAS  Google Scholar 

  9. Yoshimura, A., Longmore, G., and Lodish, H. 1990. Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity. Nature 348: 647.

    Article  CAS  Google Scholar 

  10. Watowich, S., Yoshimura, A., Longmore, G., Hilton, D., Yoshimura, Y., and Lodish, H. 1992. Homodimerization and constitutive activation of the erythropoietin receptor. Proc. Natl. Acad. Sci. U.S.A. 89: 2140–2144.

    Article  CAS  Google Scholar 

  11. D'Andrea, A., Yoshimura, A., Youssoufian, H., Zon, L., Koo, J.-W., and Lodish, H. 1991. The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains. Mol Cell. Bio. 11: 1980–1987.

    Article  CAS  Google Scholar 

  12. Fuh, F., Cunningham, B., Fukunaga, R., Nagata, S., Goeddel, D., and Wells, J. 1992. Rational design of potent antagonists to the human growth hormone receptor. Science 256: 1677–1680.

    Article  CAS  Google Scholar 

  13. Lin, H., Wang, X.F., Ng-Eaton, E., Weinberg, R., and Lodish, H. 1992. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell 68: 775–785.

    Article  CAS  Google Scholar 

  14. Lin, H., and Lodish, H. 1993. Receptors for the TGF-beta superfamily: multiple polypeptides and serine/threonine kinases. Trends Cell Biol. in press.

Download references

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  1. senior editor of Bio/Technology,

    Stephen M. Edgington

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Edgington, S. Superfamily Structure and Biotech Drug Development. Nat Biotechnol 10, 1529–1534 (1992). https://doi.org/10.1038/nbt1292-1529

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