Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Tumor reactive T cells get a boost

Stimulating engineered T cells with a powerful immunogen enhances their ability to kill tumor cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Engineering altered specificity and enhanced activity into anti-tumor T cells.

References

  1. Pardoll, D.M. Nat. Rev. Immunol. 2, 227–238 (2002).

    Article  CAS  Google Scholar 

  2. Kershaw, M.H., Westwood, J.A. & Hwu, P. Nat. Biotechnol. 20, 1221–1227, (2002).

    Article  CAS  Google Scholar 

  3. Dudley, M.E. et al. Science 298, 850–854 (2002).

    Article  CAS  Google Scholar 

  4. Yee, C. et al. Proc. Natl. Acad. Sci. USA, in press (2002).

  5. Liu, X., Peralta, E.A., Ellenhorn, J.D. & Diamond, D.J. Cancer Res. 60, 693–701 (2000).

    CAS  PubMed  Google Scholar 

  6. Gross, G., Waks, T. & Eshhar, Z. Proc. Natl. Acad. Sci. USA. 86, 10024–10028 (1989).

    Article  CAS  Google Scholar 

  7. Irving, B.A. & Weiss, A. Cell. 64, 891–901 (1991).

    Article  CAS  Google Scholar 

  8. Eshhar, Z., Waks, T., Gross, G. & Schindler, D.G. Proc. Natl. Acad. Sci. USA. 90, 720–724 (1993).

    Article  CAS  Google Scholar 

  9. Hwu, P. et al. J. Exp. Med. 178, 361–366 (1993).

    Article  CAS  Google Scholar 

  10. Schwartz, R.H. Cell 71, 1065–1068 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pardoll, D. Tumor reactive T cells get a boost. Nat Biotechnol 20, 1207–1208 (2002). https://doi.org/10.1038/nbt1202-1207

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1202-1207

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing