Abstract
Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.
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Acknowledgements
We thank Zouhair Sbiaa and Michael Finot (Micralyne) for producing the microchips used in this study, and all members of the MicroCHIPS team, past and present, who participated in developing this technology and in the practical demonstration of its utility in vivo.
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The authors are current or former employees of MicroCHIPS, Inc. and possess stock or stock options in MicroChips, Inc.
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Supplementary Fig. 1
In vitro leuprolide release kinetics. (PDF 14 kb)
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Prescott, J., Lipka, S., Baldwin, S. et al. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device. Nat Biotechnol 24, 437–438 (2006). https://doi.org/10.1038/nbt1199
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DOI: https://doi.org/10.1038/nbt1199
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