Gene therapy may prove useful for progressive re-obstruction of coronary angioplasties, a widespread condition that has proved difficult to treat pharmacologically. On page 1181, Levy and colleagues address the problem of how to achieve localized and sustained delivery of therapeutic DNA to sites of angioplasty. They developed a polymer impregnated with the plasmid DNA that, when coated onto a stent (a metallic tube that expands to open blocked coronary arteries) releases DNA without causing inflammation or interfering with stent mechanics. When implanted into pig coronary arteries, a stent coated with the polymer releasing the GFP gene transfected ∼1% of arterial cells, as shown by immunofluorescence. Once it's clear which genes will have the best therapeutic effect, such sustained-release localized delivery methods can improve treatment for a variety of vascular injuries.