Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Introducing the acetylome

Mass spectrometry reveals protein acetylation to be as widespread as phosphorylation.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Residues that most frequently surround sites of protein acetylation.

References

  1. Allfrey, V.G., Faulkner, R. & Mirsky, A.E. Proc. Natl. Acad. Sci. USA 51, 786–794 (1964).

    Article  CAS  Google Scholar 

  2. Choudhary, C. et al. Science 325, 834–840 (2009).

    Article  CAS  Google Scholar 

  3. van Attikum, H. & Gasser, S.M. Trends Cell Biol. 19, 207–217 (2009).

    Article  CAS  Google Scholar 

  4. Lee, K.K. & Workman, J.L. Nat. Rev. Mol. Cell Biol. 8, 284–295 (2007).

    Article  CAS  Google Scholar 

  5. Spange, S., Wagner, T., Heinzel, T. & Kramer, O.H. Int. J. Biochem. Cell Biol. 41, 185–198 (2009).

    Article  CAS  Google Scholar 

  6. Olsen, J.V. et al. Cell 127, 635–648 (2006).

    Article  CAS  Google Scholar 

  7. Basu, A. et al. Proc. Natl. Acad. Sci. USA 106, 13785–13790 (2009).

    Article  CAS  Google Scholar 

  8. Khan, O. & La Thangue, N.B. Nat. Clin. Pract. Oncol. 5, 714–726 (2008).

    Article  CAS  Google Scholar 

  9. Wiech, N.L., Fisher, J.F., Helquist, P. & Wiest, O. Curr. Top. Med. Chem. 9, 257–271 (2009).

    Article  CAS  Google Scholar 

  10. Witt, O., Deubzer, H.E., Milde, T. & Oehme, I. Cancer Lett. 277, 8–21 (2009).

    Article  CAS  Google Scholar 

  11. Shukla, V., Vaissiere, T. & Herceg, Z. Mutat. Res. 637, 1–15 (2008).

    Article  CAS  Google Scholar 

  12. Huangfu, D. et al. Nat. Biotechnol. 26, 795–797 (2008).

    Article  CAS  Google Scholar 

  13. Huangfu, D. et al. Nat. Biotechnol. 26, 1269–1275 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jerry L Workman.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Smith, K., Workman, J. Introducing the acetylome. Nat Biotechnol 27, 917–919 (2009). https://doi.org/10.1038/nbt1009-917

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1009-917

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing