Characterization of novel multifunctional proteins involved in assembly of the enediyne natural products C-1027 and calicheamicin furthers the potential of combinatorial biosynthesis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Liu, Y. et al. Science 297, 1170–1173 (2002).
Ahlert, J. et al. Science 297, 1173–1176 (2002).
Sievers, E.L. & Linenberger, M. Curr. Opin. Oncol. 13, 522 (2001).
Du, L. et al. Metabolic Eng. 3, 78–95 (2001).
Cane, D.E. & Walsh, C.T. Chem. Biol. 6, R319–R325 (1999).
Rudd, B.A.M. & Hopwood, D.A. J. Gen. Microbiol. 114, 35–43 (1979).
Sherman, D.H. et al. EMBO J. 9, 2717–2725 (1989).
Bibb, M.J. et al. EMBO J. 9, 2727–2736 (1989).
Hopwood, D.A. & Sherman, D.H. Annu. Rev. Genet. 24, 37–66 (1990).
Kwon, H.-J. et al. Science 297, 1327–1330 (2002).
Cane, D.E. Chem. Rev. 97, 2463–2706 (1997).
Moore, B.S. & Hopke, J.N. ChemBioChem. 2, 35–38 (2001).
Xi, Z. & Goldberg, I.H. in Comprehensive Natural Products Chemistry Vol. 7 (eds Barton, D., Nakanishi, K. & Meth-Cohn, O.) 553–592 (Elsevier, New York, 1999).
Metz, J.G. et al. Science 293, 290–293 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sherman, D. New enzymes for “warheads”. Nat Biotechnol 20, 984–985 (2002). https://doi.org/10.1038/nbt1002-984
Issue Date:
DOI: https://doi.org/10.1038/nbt1002-984
