Professional antigen-presenting cells (APCs) are potent stimulators of T-cell-mediated immune responses. On page 974, Chattergoon et al. describe a method for enhancing cytotoxic T-lymphocyte responses to an antigen of choice. They co-injected DNA encoding the desired antigen along with DNA encoding the Fas protein (a receptor that plays a role in cell death mechanisms) into the muscle of mice. The Fas-mediated death of these antigen-bearing cells resulted in increased antigen acquisition by APCs and enhanced antigen-specific cytotoxic T-lymphocyte responses. Increasing delivery of antigen to APCs could potentially improve the potency of immunotherapies.
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Sinclair, M. Improving antigen delivery. Nat Biotechnol 18, 915 (2000). https://doi.org/10.1038/79364
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DOI: https://doi.org/10.1038/79364