Professional antigen-presenting cells (APCs) are potent stimulators of T-cell-mediated immune responses. On page 974, Chattergoon et al. describe a method for enhancing cytotoxic T-lymphocyte responses to an antigen of choice. They co-injected DNA encoding the desired antigen along with DNA encoding the Fas protein (a receptor that plays a role in cell death mechanisms) into the muscle of mice. The Fas-mediated death of these antigen-bearing cells resulted in increased antigen acquisition by APCs and enhanced antigen-specific cytotoxic T-lymphocyte responses. Increasing delivery of antigen to APCs could potentially improve the potency of immunotherapies.