Peptide nucleic acids (PNAs) are stable peptide-based DNA mimics used as gene delivery vehicles. An important limiting factor in gene delivery is nuclear transfer of the transfected DNA. Branden et al. (p.784) have fused a PNA to a nuclear localization signal (NLS), demonstrating that the chimera can effect efficient nuclear delivery and gene expression of a hybridized plasmid.
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Frederickson, R. PNA–NLS delivers. Nat Biotechnol 17, 739 (1999). https://doi.org/10.1038/11657
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DOI: https://doi.org/10.1038/11657