On page 857, Velasco et al. report an environmentally friendly and high-yield bioprocess for production of cephalosporin antibiotics. Currently, this class of antibiotics is produced by an expensive and environmentally harmful semisynthetic method. Previous attempts have failed to efficiently produce by fermentation deacetoxycephalosporin C (DAOC), a crucial intermediate in the production of semisynthetic derivatives of cephalosporins. But Velasco et al. got around these problems by deleting the cefEF gene in the industrial fungal strain Acremonium chrysogenum and replacing it with the bacterial cefE gene that can produce high yields of DAOC, a starting material for production of 7-aminodeacetocephalosporanic acid (7-ADCA), from which all derivatives of cephalosporins are manufacured.