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Recombinant Polymeric IgG: An Approach to Engineering More Potent Antibodies

Bio/Technology volume 12, pages 683–688 (1994)Cite this article

Abstract

IgM and IgG are the only classes of immunoglobulin capable of initiating the classical complement cascade. IgM, however, fixes complement much more effectively than IgG making it a more attractive Fc for some immunotherapeutic strategies. IgG, on the other hand, triggers additional effector functions mediated through γ specific Fc receptors. Using a generalizable technique we have produced IgM-like polymers of IgG that possess both the Fcγ receptor binding properties of IgG and the more potent complement activity of IgM.

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Author notes

  1. Sherie L. Morrison: Corresponding author.

Authors and Affiliations

  1. Department of Microbiology and Molecular Genetics and the Molecular Biology Institute, University of California, Los Angeles, CA, 90024

    Richard I. F. Smith & Sherie L. Morrison

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  1. Richard I. F. Smith
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Smith, R., Morrison, S. Recombinant Polymeric IgG: An Approach to Engineering More Potent Antibodies. Nat Biotechnol 12, 683–688 (1994). https://doi.org/10.1038/nbt0794-683

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