Abstract
Is cancer really caused by cells refusing to commit suicide on cue?
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References
Barres, B., Hart, I., Coles, H., Burne, J., Voyvodic, J., Richardson, W. and Raff, M. 1992. Cell death and control of cell survival in the oligodendrocyte lineage. cell 70: 31–46.
Ellis, H. and Horvitz, H. 1986. Genetic control of programmed cell death in the nematode C. elegans. cell 44: 817–829.
Hengartner, M., Ellis, R. and Horvitz, H. 1992. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356: 494–499.
Askew, D., Ashmun, R., Simmons, B. and Cleveland, J. 1991. Constitutive c-myci expression in an Il-3-dependent myeloid cell line suppressed cell cycle arrest and accelerates apoptosis. Oncogens 6: 1915–1922.
Shi, Y., Bissonnette, R., Glynn, J., Guilbert, L., Cotter, T. and Green, D. 1992. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257: 212–214.
Bissonnette, R., Echeverri, F., Mahboubi, A. and Green, D. 1992. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359: 552–554.
Smeyne, R., Vendrell, M., Hayward, M., Baker, S., Miso, G., Schilling, K., Robertson, L., Curran, T. and Morgan, J. 1993. Continuous c-fos expression precedes programmed cell death in vivo. Nature 363: 168–169.
Lowe, S., Schmitt, E., Smith, S., Osborne, B. and Jacks, T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847–849.
Clarke, A., Purdie, C., Harrison, D., Morris, R., Bird, C., Hooper, M. and Wyllie, A. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362: 849–852.
Miyashita, T. and Reed, J. 1993. Bcl-2 oncoprotein blocks chemo therapy-induced apoptosis in a human leukemia cell line. Blood 81: 151–157.
Reed, J., Stein, C., Subasinghe, C., Haldar, S., Croce, C., Yum, S. and Cohen, J. 1990.Antisense mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: Comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides. Cancer Research 50: 6565–6570.
Curran, T. and Morgan, J. 1985. Superinduction by fos by nerve growth factor in the presence of peripherally active benzodiaz epines. Science 229: 1265–1268.
Tian, Q., Streuli, M., Saito, H., Schlossman, S. and Anderson, P. 1991. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. cell 67: 629–639.
Tomei, D., Shapiro, J. and Cope, F. 1993. Apoptosis in C3H/101/2 mouse embryonic cells: Evidence for internucleosomal DNA modification in the absence of double-strand cleavage. Proc. Natl. Acad. Sci. U.S.A. 90: 853–857.
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Edgington, S. Looking Death In The Eye: Apoptosis And Cancer Research. Nat Biotechnol 11, 787–792 (1993). https://doi.org/10.1038/nbt0793-787
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DOI: https://doi.org/10.1038/nbt0793-787
