Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Chemokines in Cardiovascular Disease

Abstract

Do chemoattractant cytokines regulate the progression of atherosclerosis?

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Cushing, S., Berliner, J., Valente, A., Territo, M., Navab, M., Parhami, F., Gerrity, R., Schwartz, C. and Fogelman, A. 1990. Minimally modified low-density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc. Natl. Acad. Sci. U.S.A. 87: 5134.

    Article  CAS  Google Scholar 

  2. Navab, M., Imes, S., Hama, S., Hough, G., Ross, L., Bork, R., Valente, A., Berliner, J., Drinkwater, D., Laks, H. and Fogelman, A. 1991. Monocyte transmigration induced by modification of low-density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. J. clin. Invest. 88: 2039.

    Article  CAS  Google Scholar 

  3. Taubman, M., Rollins, B., Poon, M., Marmur, J., Green, R., Berk, B. and Nadal-Ginard, B. 1992. JE mRNA accumulates rapidly in aortic injury and in platelet-derived growth factor-stimulated vascular smooth muscle cells. Circ. Res. 70: 314–323.

    Article  CAS  Google Scholar 

  4. Kameyoshi, Y., Dorschner, A., Mallet, A., Christophers, E. and Schroder, J.-M. 1992. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J. Exp. Med. 176: 587–592.

    Article  CAS  Google Scholar 

  5. Schall, T., Bacon, K., Toy, K. and Goeddel, D. 1990. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 347: 669–671.

    Article  CAS  Google Scholar 

  6. Rollins, B., Yoshimura, T., Leonard, E. and Pober, J. 1990. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. AJP 136: 1229–1233.

    CAS  PubMed  Google Scholar 

  7. Yu, X., Dluz, S., Graves, D., Zhang, L., Antoniades, H., Hollander, W., Prusty, S., Valente, A., Schwartz, C. and Sonenshein, G. 1992. Elevated expression of monocyte chemoattractant protein 1 by vascular smooth muscle cells in hypercholesterolemic primates. Proc. Natl. Acad. Sci. U.S.A. 89: 6953–6957.

    Article  CAS  Google Scholar 

  8. Tanaka, Y., Adams, D., Hubscher, S., Hirano, H., Siebenlist, U. and Shaw, S. S.1993. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β. Nature 361: 79–82.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Edgington, S. Chemokines in Cardiovascular Disease. Nat Biotechnol 11, 676–681 (1993). https://doi.org/10.1038/nbt0693-676

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0693-676

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing