In this issue, Kornblum and coworkers report that a new technology designed for small-animal imaging, microPET, can provide high-resolution images of metabolic function in the conscious rat brain, and patterns of neuronal activity during seizures and physiological stimuli. They also demonstrate its usefulness for imaging neuronal depression and metabolic activity in the rat brain in a model of human epilepsy surgery. MicroPET may prove a useful tool for in vivo rodent models in the study and development of novel therapeutics for epilepsy, brain injury, and other disorders of the brain (see p. 655).