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Antigen Engineering in Yeast: Synthesis and Assembly of Hybrid Hepatitis B Surface Antigen-Herpes Simplex 1 gD Particles

Bio/Technology volume 3, pages 323–326 (1985)Cite this article

Abstract

A new approach for antigen presentation and polyvalent vaccines is tested. The idea is to recombine the gene of a second immunogen with that of hepatitis B surface antigen so that the second immunogen is assembled into, and presented on the surface of the HBsAg particle. We describe here the synthesis and assembly in yeast of a model hybrid particle containing both, hepatitis B virus and herpes simplex virus surface antigens.

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Authors and Affiliations

  1. Chiron Research Laboratories, Chiron Corporation, 4560 Horton Street, Emeryville, CA, 94608

    Pablo Valenzuela, Doris Coit, M. Angelica Medina-Selby, Ching H. Kuo, Gary Van Nest, Rae Lyn Burke, Paulina Bull, Mickey S. Urdea & Pierre V. Graves

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  1. Pablo Valenzuela
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  2. Doris Coit
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  3. M. Angelica Medina-Selby
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  4. Ching H. Kuo
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  5. Gary Van Nest
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  6. Rae Lyn Burke
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  7. Paulina Bull
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  8. Mickey S. Urdea
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  9. Pierre V. Graves
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Valenzuela, P., Coit, D., Medina-Selby, M. et al. Antigen Engineering in Yeast: Synthesis and Assembly of Hybrid Hepatitis B Surface Antigen-Herpes Simplex 1 gD Particles. Nat Biotechnol 3, 323–326 (1985). https://doi.org/10.1038/nbt0485-323

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  • DOI: https://doi.org/10.1038/nbt0485-323

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