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siRNAs with guts

Nature Biotechnology volume 26, pages 403–405 (2008)Cite this article

Leukocyte-directed, small interfering (si)RNA against cyclin D1 shows promise for treatment of inflammatory bowel disease.

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Figure 1: Preparation of integrin-targeted stable nanoparticles entrapping siRNA.

References

  1. Peer, D., Park, E.J., Morishita, Y., Carman, C.V. & Shimaoka, M. Science 319, 627–630 (2008).

    Article  CAS  Google Scholar 

  2. Park, E.J. et al. J. Immunol. 171, 4131–4139 (2003).

    Article  CAS  Google Scholar 

  3. Felgner, P.L. Hum. Gene Ther. 8, 511–512 (1997).

    Article  CAS  Google Scholar 

  4. Hope, M.J., Bally, M.B., Webb, G. & Cullis, P.R. Biochim. Biophys. Acta 812, 55–65 (1985).

    Article  CAS  Google Scholar 

  5. Behlke, M.A. Mol. Ther. 13, 644–670 (2006).

    Article  CAS  Google Scholar 

  6. Vijay-Kumar, M. et al. Inflamm. Bowel Dis. 13, 856–864 (2007).

    Article  Google Scholar 

  7. Judge, A.D., Bola, G., Lee, A.C.H. & MacLachlan, I. Mol. Ther. 13, 494–505 (2006)

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Ian MacLachlan is at Protiva Biotherapeutics Inc., 100-3480 Gilmore Way, Burnaby, BC, Canada, V5G 4Y1. ian@protivabio.com,

    Ian MacLachlan

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  1. Ian MacLachlan
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Competing interests

I.M. is an employee and shareholder of Protiva Biotherapeutics Inc., a company engaged in the development of siRNA-based drugs and their associated delivery systems.

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MacLachlan, I. siRNAs with guts. Nat Biotechnol 26, 403–405 (2008). https://doi.org/10.1038/nbt0408-403

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