Surging numbers of therapeutic proteins and small molecules, rationally designed to trigger cell death, are entering the clinic against cancer. In theory, they should provide an entirely new kind of targeted therapy, but troubling questions of basic biology remain.
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References
Li, L. et al. A small molecule Smac mimic potentiates trail- and TNFα-mediated cell death. Science 305, 1471 - 1474 (2004).
Diehl, G.E. et al., TRAIL-R as a negative regulator of innate immune cell responses, Immunity 21, 887 - 889 (2004).
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Garber, K. New apoptosis drugs face critical test. Nat Biotechnol 23, 409–411 (2005). https://doi.org/10.1038/nbt0405-409
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DOI: https://doi.org/10.1038/nbt0405-409
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