Abstract
It's not uncommon to hear pilot–plant personnel complaining about the impractical purification schemes Research has handed them—poorly defined operating conditions and multistep–protocols using expensive, hard–to–maintain media are perhaps the most frequent gripes. Yet regulatory considerations may lock the pilot or production plant into that single, cumbersome protocol. Considerable time, money, and aggravation may be saved by pausing at laboratory scale to consider cost, regulatory demands, and effective scale–up of the options in chromatographic purification.
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Sofer, G., Mason, C. From R&D to Production: Designing a Chromatographic Purification Scheme. Nat Biotechnol 5, 239–244 (1987). https://doi.org/10.1038/nbt0387-239
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DOI: https://doi.org/10.1038/nbt0387-239