Change, continuing change, inevitable change is a pervasive factor in biotechnology. And so, this issue, which marks the fifth anniversary of Nature Biotechnology's relaunch, brings changes in the journal's design intended to improve accessibility of content. Some of these changes are cosmetic; they aim to enhance the appearance, provide a greater feeling of continuity between sections, and embrace a more modern and cleaner layout. Others are more functional; we have introduced design elements to simplify navigation through the journal and ordered sections to provide a better pace of read. Most significantly, we have clearly delineated front-half news and analysis material into Business and Regulatory News, and Research News (we recognize this is a rather artificial distinction, given the interdependence of business and research in biotechnology). A new monthly article on Careers & Recruitment and an expanded classified section in Nature Jobs Biotechnology also starts on p. 285.