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Sustained local drug delivery from a radiopaque implanted reservoir

Nature Biotechnology volume 16, pages 172–176 (1998)Cite this article

Abstract

A new polymeric biomaterial that contains covalently bound iodine, and is therefore radiopaque, was used to construct a sustained local drug-delivery device. A polymeric wall was designed to be porous (i.e., passage of low-molecular-weight molecules across the wall is possible), self-healing, and biocompatible. Once implanted, the sphere cavity can be filled and refilled with a concentrated solution of a (cytostatic) drug, which is subsequently released by slow diffusion into the tissue region surrounding the sphere. This principle of sustained local drug delivery is shown by a series of in vitro experiments on the release of 5-fluorouracil, and in vivo animal experiments, using x-ray fluoroscopic and scintigraphic techniques.

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Authors and Affiliations

  1. Centre for Biomaterials Research, University of Maastricht, PO Box 616, 6200 MD, Maastricht, The Netherlands

    Leo H. Koole, Marc-Anton B. Kruft, Yvette B.J. Aldenhoff & Nicolette E. van 't Oost

  2. Department of Nuclear Medicine, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, The Netherlands

    Yvette B.J. Aldenhoff & Marinus J.P.G. van Kroonenburgh

  3. Department of Cardiology, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, The Netherlands

    Frederik H. van der Veen

Authors
  1. Leo H. Koole
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  2. Marc-Anton B. Kruft
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  3. Yvette B.J. Aldenhoff
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  4. Nicolette E. van 't Oost
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  5. Marinus J.P.G. van Kroonenburgh
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  6. Frederik H. van der Veen
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Correspondence to Leo H. Koole.

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Koole, L., Kruft, MA., Aldenhoff, Y. et al. Sustained local drug delivery from a radiopaque implanted reservoir. Nat Biotechnol 16, 172–176 (1998). https://doi.org/10.1038/nbt0298-172

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