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  • Review Article
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Rational Immunotherapy with Interleukin 2

Bio/Technology volume 10, pages 157–162 (1992)Cite this article

Abstract

Interleukin 2 (IL-2), a T lymphocytes product released upon antigen stimulation, has been used for cancer therapy in high doses for more than five years. More recently, its potential as a stimulant of cell-meidated immunity in infectious diseases, particularly those caused by intracellular microbes, has become appreciated. Drawing on the extensive information available as to the structure, cellular and molecular effects of IL-2, this review focuses on its use in patients with lepromatous leprosy and AIDS in low, physiologic doses. The data indicate that IL-2 is effective in stimulating cell-mediated immunity without systemic toxicity.

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Authors and Affiliations

  1. The Laboratory of Cellular Physiology & Immunology, The Rockefeller University, 1230 York Avenue, New York, NY, 10021

    Gilla Kaplan & Zanvil A. Cohn

  2. The Department of Medicine, Dartmouth Medical School, Hanover, NH, 03756

    Kendall A. Smith

Authors
  1. Gilla Kaplan
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  2. Zanvil A. Cohn
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  3. Kendall A. Smith
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Kaplan, G., Cohn, Z. & Smith, K. Rational Immunotherapy with Interleukin 2. Nat Biotechnol 10, 157–162 (1992). https://doi.org/10.1038/nbt0292-157

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