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DNA variation and the future of human genetics

Nature Biotechnology volume 16, pages 33–39 (1998)Cite this article

Abstract

The use of DNA variants in the mapping of the human genome and in the positional cloning of monogenie disease genes is well established. Determining the genetic bases of the more common “multifactorial” diseases, however, presents a major challenge. The genetics of these diseases are complicated by the interplay between many genes and the environment. These investigations will require large numbers of DNA markers and the technology to screen large populations with these markers. The systematic identification of the common DNA polymorphisms in the human genome coupled with the development of high throughput screening methods should allow ultimately the elucidation of the genetic component of most clinical and nonclinical phenotypes.

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  1. Hexagen, 214 Cambridge Science Park, Milton Rd., Cambridge, CB4 4WA, UK

    Alan J. Schafer

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    J. Ross Hawkins

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Schafer, A., Hawkins, J. DNA variation and the future of human genetics. Nat Biotechnol 16, 33–39 (1998). https://doi.org/10.1038/nbt0198-33

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