Correcting defective genes at the mRNA level shows promise for the treatment of cystic fibrosis.
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References
Liu, X. et al. Nat. Biotechnol. 20, 47–52 (2002).
Welsh, M.J., Tsui, L.-C., Boat, T.F. & Beaudet, A.L. In The metabolic and molecular basis of inherited disease. (eds Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D.) 3799–3876 (McGraw-Hill, New York, NY; 1995).
Korst, R.J. et al. Am. J. Respir. Crit. Care Med. 151 (Suppl.), S75–S87 (1995).
Hodges, D. & Bernstein, S.I. Adv. Genet. 31, 207–281 (1994).
Moore, M.J., Query, C.C. & Sharp, P.A. In The RNA World. (ed. Gesteland, R.F.) 303–358 (Cold Spring Harbor Laboratory Press, old Spring Harbor, NY; 1993).
Spector, D.L. Curr. Opin. Cell Biol. 5, 442–447 (1993).
Harris, N.L. & Senapathy, P. Nucleic Acids Res. 18, 3015–3019 (1990).
Stephens, R.M. & Schneider, T.D. J. Mol. Biol. 228, 1124–1136 (1992).
Puttaraju, M., DiPasquale, J., Baker, C.C., Mitchell, L.G. & Garcia-Blanco, M.A. Mol. Ther. 4, 105–114 (2001).
Bonen, L. FASEB J. 7, 40–46 (1993).
Caudevilla, C. et al. Proc. Natl. Acad. Sci. USA 95, 12185–12190 (1998).
Dallinger, G. et al. J. Invest. Dermatol. 115, 332 (2000).
Mansfield, S.G. et al. Gene Ther. 7, 1885–1895 (2000).
Puttaraju, M., Jamison, S.F., Mansfield, S.G., Garcia-Blanco, M.A. & Mitchell, L.G. Nat. Biotechnol. 17, 246–252 (1999).
Kikumori, T., Cote, G.J. & Gagel, R.F. Hum. Gene Ther. 12, 1429–1441 (2001).
Crystal, R.G. Science 270, 404–410 (1995).
Wilson, J.M. N. Engl. J. Med. 334, 1185–1187 (1996).
Bosch, A., Perret, E., Desmaris, N., Trono, D. & Heard, J.M. Hum. Gene Ther. 11, 1139–1150 (2000).
Herzog, R.W. et al. Proc. Natl. Acad. Sci. USA 94, 5804–5809 (1997).
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Crystal, R. Fooling Mother Nature. Nat Biotechnol 20, 32–33 (2002). https://doi.org/10.1038/nbt0102-32
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DOI: https://doi.org/10.1038/nbt0102-32