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Microscale sample preparation

Nature Biotechnology volume 18, pages 104–105 (2000)Cite this article

Abstract

The demand for microscale analysis has stimulated the development of new solid phase formats in sample preparation.

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Figure 1: Scanning electron microscopy analysis of the expanded chromatography bed in the ZipTip format.
Figure 2: Desalting in-gel digests using a Zip TipC18 for MALDI mass spectrometry analysis: human IgG heavy chain endo lys-c digest.
Figure 3: MALDI TOF mass spectra of oligonucleotides either (A) untreated or (B) after clean up on a ZipTipC18 micropipet device.

References

  1. IBC Annual Conference on Sample Preparation, June 24–25, 1999, San Francisco, CA.

  2. Lingeman, H. & Hoekstra-Oussoren, S.J. J. Chromatogr. B 689, 221–237 (1999).

    Article  Google Scholar 

  3. Simpson, H. et al. Rapid Commun. Mass Spectrom. 12, 75–82 (1998).

    Article  CAS  Google Scholar 

  4. Plumb R.S. et al. J. Chromatogr. B 694, 123–133 (1997).

    Article  CAS  Google Scholar 

  5. Wilm, M. & Mann, M. Anal. Chem. 66, 1–8 (1996).

    Article  Google Scholar 

  6. Annan, R.S. et al. International Symposium ABRF'96, San Francisco, CA. Abstract S73 (1996).

  7. Erdjument-Bromage, H. et al. Chromatogr. A 826, 167–181 (1998).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. biotechnology writer and consultant,

    Malcolm G. Pluskal

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  1. Malcolm G. Pluskal
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Pluskal, M. Microscale sample preparation. Nat Biotechnol 18, 104–105 (2000). https://doi.org/10.1038/71778

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