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  • Clinical Techniques
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Using the facial grimace scale to evaluate rabbit wellness in post-procedural monitoring

Lab Animal volume 44, pages 259–260 (2015)Cite this article

Abstract

Rabbits are commonly used in biomedical research and might undergo potentially painful procedures during the course of a study. This column discusses the rabbit facial grimace scale as a tool for monitoring post-procedural pain and explains how it can be incorporated into a worksheet for evaluating rabbit wellness.

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Figure 1: Rabbit FGS.

References

  1. US Department of Agriculture. Animals Used in Research 2013. http://www.aphis.usda.gov/animal_welfare/downloads/7023/Animals%20Used%20In%20Research%202013.pdf

  2. Weaver, L.A., Blaze, C.A., Linder, D.E., Andrutis, K.A. & Karas, A.Z. A model for clinical evaluation of perioperative analgesia in rabbits (Oryctolagus cuniculus). J. Am. Assoc. Lab. Anim. Sci. 49, 845–851 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Lipman, N.S., Marini, R.P. & Flecknell, P.A. Anesthesia and analgesia in rabbits. in Anesthesia and Analgesia in Laboratory Animals (eds. Kohn, D.F., Wixson, S.K., White, W.J. & Benson, G.J.) 205–232 (Academic, Boston, 1997).

    Chapter  Google Scholar 

  4. Lipman, N.S., Marini, R.P. & Flecknell, P.A. Anesthesia and analgesia in rabbits. in Anesthesia and Analgesia in Laboratory Animals 2nd edn. (eds. Fish, R.E., Brown, M.J., Danneman, P.J. & Karas, A.Z.) (Academic, Boston, 2008).

    Google Scholar 

  5. Parga, M.L. Assessment of the efficacy of meloxicam and development of a pain scoring system based on behavior in rabbits undergoing elective surgery. BSAVA Congress 2003 Scientific Proceedings. (Birmingham, UK, 2003).

  6. Roughan, J.V., Flecknell, P.A. & Orr, H.E. Behavioral assessment of postoperative pain and analgesic effects of carprofen in the domestic rabbit. in Proceedings of the Eighth World Congress of Veterinary Anaesthesia (University of Tennessee, Knoxville, TN, 2003).

    Google Scholar 

  7. Gross, D.M. Defending the humanities with Charles Darwin's The Expression of the Emotions in Man and Animals (1872). in The Secret History of Emotion: from Aristotle's Rhetoric to Modern Brain Science 34–59 (University of Chicago, Chicago, IL, 2007).

    Google Scholar 

  8. Gleerup, K.B., Forkman, B., Lindegaard, C. & Andersen, P.H. An equine pain face. Vet. Anaesth. Analg. 42, 103–114 (2015).

    Article  Google Scholar 

  9. Holden, E. et al. Evaluation of facial expression in acute pain in cats. J. Small Anim. Pract. 55, 615–621 (2014).

    Article  CAS  Google Scholar 

  10. Langford, D.J. et al. Coding of facial expressions of pain in the laboratory mouse. Nat. Methods 7, 447–449 (2010).

    Article  CAS  Google Scholar 

  11. American College of Laboratory Animal Medicine. Guidelines for the Assessment and Management of Pain in Rodents and Rabbits (American College of Laboratory Animal Medicine, 2006).

  12. Keating, S.C., Thomas, A.A., Flecknell, P.A. & Leach, M.C. Evaluation of EMLA cream for preventing pain during tattooing of rabbits: changes in physiological, behavioral, and facial expression responses. PLoS ONE 7, e44437 (2012).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Capital Preclinical Scientific Research Consultants, LLC, Bethesda, MD

    Victoria Hampshire

  2. College of Veterinary Medicine, Michigan State University, East Lansing, MI

    Sheilah Robertson

Authors
  1. Victoria Hampshire
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  2. Sheilah Robertson
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Correspondence to Victoria Hampshire.

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Hampshire, V., Robertson, S. Using the facial grimace scale to evaluate rabbit wellness in post-procedural monitoring. Lab Anim 44, 259–260 (2015). https://doi.org/10.1038/laban.806

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