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An association between resistant hypertension and the null GSTM1 genotype

Journal of Human Hypertension volume 23, pages 556–558 (2009)Cite this article

Abstract

Reduction in expression levels of glutathione S -transferase (GST) μ type 1 (GSTM1) in stroke-prone spontaneously hypertensive rats has recently been reported. GSTM1 genotype was evaluated in 49 patients with resistant hypertension and compared with selected patients with controlled hypertension ( n =232) and healthy participants ( n =110). Null GSTM1 genotype occurred more frequent in patients with resistant hypertension than those with controlled hypertension (57.1 vs 39.7%; P =0.03; RR 1.96; 95% CI 1.04–3.69) suggesting that null GSTM1 genotype may predispose to resistant hypertension.

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Authors and Affiliations

  1. Cardiology Department, University Hospital of Salamanca, Salamanca, Spain

    I Cruz-Gonzalez & C Martin-Luengo

  2. Department of Medicine, Molecular Medicine Unit, University of Salamanca, Salamanca, Spain

    E Corral & R Gonzalez-Sarmiento

  3. Department of Medicine, Internal Medicine Unit, University Hospital of Salamanca, Salamanca, Spain

    M Sanchez-Ledesma & A Sanchez-Rodriguez

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  1. I Cruz-Gonzalez
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  2. E Corral
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  3. M Sanchez-Ledesma
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  4. A Sanchez-Rodriguez
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  5. C Martin-Luengo
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  6. R Gonzalez-Sarmiento
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Correspondence to I Cruz-Gonzalez.

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Cruz-Gonzalez, I., Corral, E., Sanchez-Ledesma, M. et al. An association between resistant hypertension and the null GSTM1 genotype. J Hum Hypertens 23, 556–558 (2009). https://doi.org/10.1038/jhh.2009.19

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