Abstract.
 We conducted chromosomal analysis of three male infants fathered by severe oligozoospermic males with Y chromosomal microdeletions through intracytoplasmic sperm injection (ICSI). Two of the infants had the same Y chromosomal microdeletions as their fathers. The third infant also had a Y chromosomal microdeletion, which was longer than that found in his father. The results confirm that Y chromosomal microdeletions are transmitted from a father to a son via ICSI and also suggest that the microdeletions may be expanded during such transmission. Genetic counseling for infertile couples contemplating ICSI is important if the male carries Y chromosomal microdeletions.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Additional information
Received: January 11, 2002 / Accepted: May 19, 2002
Rights and permissions
About this article
Cite this article
Komori, S., Kato, H., Kobayashi, S. et al. Transmission of Y chromosomal microdeletions from father to son through intracytoplasmic sperm injection. J Hum Genet 47, 465–468 (2002). https://doi.org/10.1007/s100380200066
Issue Date:
DOI: https://doi.org/10.1007/s100380200066
This article is cited by
-
Incidence of Y chromosome microdeletions in patients with Klinefelter syndrome
Journal of Endocrinological Investigation (2019)
-
Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm
Journal of Assisted Reproduction and Genetics (2013)
-
Y chromosome microdeletions in infertile men with idiopathic oligo- or azoospermia
Journal of Experimental & Clinical Assisted Reproduction (2006)