Abstract
The transcriptional factor nuclear factor kappa-beta (NFKB) consists of a multicomponent protein complex that plays a major role in the regulation of many viral and cellular genes. The NFKB complex has two alternative DNA binding subunits. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the NFKB subunit 1 (NFKB1) gene located at 4q23–24. High heterozygosity (0.813) makes this polymorphism a useful marker in the genetic study of disorders affecting the immune response and cell differentiation.
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Received: October 19, 1998 / Accepted: November 21, 1998
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Ota, N., Nakajima, T., Shirai, Y. et al. Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor kappa-beta subunit 1 (NFKB1) locus. J Hum Genet 44, 129–130 (1999). https://doi.org/10.1007/s100380050125
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DOI: https://doi.org/10.1007/s100380050125
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