Summary
C7 polymorphism was investigated in a Japanese population (Tokyo). The C7 protein concentrations and hemolytic C7 activities in the serum samples of various phenotypes were measured by radial immuno-diffusion (RID) and radial diffusion hemolysis (RDH). The mean C7 protein levels for the common phenotypes C7 1, C7 2-1, C7 3-1, and C7 4-1 were 88%, 103%, 63%, and 94% of a standard, while the mean C7 activity levels were 96%, 90%, 63%, and 74%, respectively. Both the protein and the activity levels for C7 3-1 were significantly lower than those determined for the most common phenotype C7 1. The mean levels in two individuals of C7 3 phenotype were only 34% in protein concentration and 47% in functional activity. Concerning the ratio of functional to immunochemical C7 (i.e. the relative specific activity), there was no difference between the phenotypes C7 1 and C7 3-1. On the other hand, the mean hemolytic activity and the relative specific activity for C7 4-1 were significantly lower than those for C7 1.
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Washio, K., Tokunaga, K., Dewald, G. et al. Human C7 polymorphism: Quantitative analysis of different phenotypes. Jap J Human Genet 33, 41–47 (1988). https://doi.org/10.1007/BF01891239
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DOI: https://doi.org/10.1007/BF01891239