Summary
Electrophoretic examination of glutamate-pyruvate transaminase (GPT) in a Japanese mother-child pair showed an atypical segregation of the GPT allele. In further investigation of the mother-grandmother pair, the phenotypes of the GPT also showed the atypical segregation. All the other genetic blood markers examined in this family were transmitted according to Mendelian inheritance. Any variant GPT could not be detected in these samples by the polyacrylamide gel electrophoresis at acidic pH. These results suggest that the silent allele for GPT exists in this Japanese family.
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Akiyama, K., Abe, K. Demonstration of a glutamate-pyruvate transaminase silent allele in a Japanese family. Jap J Human Genet 29, 353–357 (1984). https://doi.org/10.1007/BF01871250
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DOI: https://doi.org/10.1007/BF01871250