Summary
Using the immunofixation isoelectric focusing method, Gc subtypes were examined in the samples with the Gc J phenotypes previously determined by immunoelectrophoresis, and it was found that theGc Js are subdivided into 4 different alleles. A population study in sera from 1,041 individuals confirmed the presence of the 4 variant alleles with the frequencies between 0.020 for the highest allele and 0.001 for the lowest one. The distribution of Gc subtypes in a Japanese population and a pedigree study from 18 families with the propositus of the variant are presented along with a description of the 2 other variants observed in the course of this study.
Similar content being viewed by others
Article PDF
References
Cleve, H., Patutschnick, W., Nevo, S., and Wendt, G. G. 1978. Genetic studies on the Gc subtypes.Human Genet. 44: 117–122.
Constans, J. and Viau, M. 1977. Group-specific component: Evidence for two subtypes of the Gc1 allele.Science 198: 1070–1071.
Constans, J., Viau, M., Cleve, H., Jaeger, G., Quilici, J. C., and Palisson, M. J. 1978a. Analysis of the Gc polymorphism in human populations by isoelectrofocusing on polyacrylamide gels. Demonstration of subtypes of the Gc1 allele and of additional Gc variants.Human Genet. 41: 53–60.
Constans, J., Viau, M., Pison, G., and Langaney, A. 1978b. Gc subtypes demonstrated by isoelectric focusing: further data and description of new variants among an African sample (Fula) from Senegal.Jap. J. Human Genet. 23: 111–117.
Hirschfeld, J. 1962. The Gc-system.Prog. Aller. 6: 155–186.
Kitchin, F. D. 1965. Demonstration of the inherited serum group-specific protein by acrylamide electrophoresis.Proc. Soc. Exp. Biol. Med. 118: 304–307.
Kuwata, M., Ishimoto, G., and Nakajima, H. 1978. Group-specific component (Gc) polymorphism in Japanese: an investigation on the phenotypic distribution with regard to the GcJ allele.Jap. J. Human Genet. 23: 127–132.
Laurell, C. B. 1965. Antigen-antibody crossed electrophoresis.Anal. Biochem. 10: 358–361.
Omoto, K., Cleve, H., and Misawa, S. 1972. A new variant phenotype of the group-specific component (Gc) found in a Japanese family.Jap. J. Human Genet. 17: 1–9.
Omoto, K. and Miyake, K. 1978. The distribution of the group-specific component (Gc) subtypes in Japanese.Jap. J. Human Genet. 23: 119–126.
Author information
Authors and Affiliations
Additional information
This study was supported by the Scientific Research Grant (337023) from the Ministry of Education, Science and Culture of Japan.
Rights and permissions
About this article
Cite this article
Ishimoto, G., Kuwata, M. & Nakajima, H. Group-specific component (Gc) polymorphism in Japanese: An analysis by isoelectric focusing on polyacrylamide gels. Jap J Human Genet 24, 75–83 (1979). https://doi.org/10.1007/BF01888924
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01888924
Keywords
This article is cited by
-
A hereditary double double-banded variation in the vitamin D-binding protein (GC) system analyzed by immunoblotting: duplication of the 1F and 1A2 genes?
Human Genetics (1989)
-
Group-specific component (Gc) subtypes in two chinese populations
Japanese journal of human genetics (1987)
-
Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations
Human Genetics (1986)
-
Das Vitamin-D-bindende Protein des menschlichen Plasmas
Naturwissenschaften (1985)
-
Haptoglobin, group-specific component, transferrin andα 1 subtypes and new variants in Japanese
Japanese journal of human genetics (1983)