Abstract
A novel gramicidin S analog, cyclo(-Val-Leu-Leu-Orn-Leu-D-Phe-Pro-)2, was synthesized, its antibiotic activity compared with gramicidin S and shown to be as potent as gramicidin S when compared with the susceptibility toward five Gram-positive microorganisms. It exceeded the activity of gramicidin S against Bacillus megaterium ATCC 19213 by a factor of two. Circular dichroism and NMR data suggested this analog to adopt an antiparallel β-sheet conformation without amphiphilic character.
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Tamaki, M., Sawa, K., Kikuchi, S. et al. A Novel, Antimicrobially Active Analog of Gramicidin S without Amphiphilic Conformation. J Antibiot 59, 370–372 (2006). https://doi.org/10.1038/ja.2006.54
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DOI: https://doi.org/10.1038/ja.2006.54
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