Abstract
Novel immunosuppressants, ushikulides A and B, were isolated from the culture broth of Streptomyces sp. IUK-102. Ushikulides A and B both have the same molecular formula, determined as C40H68O10. The structures of both compounds were elucidated to be novel 22-membered macrolides. Both compounds showed immunosuppressive activity for murine splenocyte proliferation in vitro.
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Dreyfuss M, Harri E, Hoffmann H, Kobel H, Pache W, Tscherter H . Cyclosporin A and C. New metabolites from Trichoderma polysporum (Linx ex Pers.) Rifai. Eur J Appl Microbiol 3: 125–133 ( 1976)
Kino T, Hatanaka H, Hashimoto M, Nishiyama M, Goto T, Okuhara M, Kohsaka M, Aoki H, Imanaka H . FK-506, a novel immunosupressant isolated from a Streptomyces. I. Frementation, isolation, and physico-chemical and biological characteristics. J Antibiot 40: 1249–1255 ( 1987)
Schreiber SL, Crabtree GR . The mechanism of action of cyclosporin A and FK506. Immunol Today 13: 136–142 ( 1992)
The US Multicenter FK506 Liver Study Group. A comparison of tacrolimus (FK506) and cyclosporin for immunosuppression in liver transplantation. N Engl J Med 331: 1110–1115 ( 1994)
Atokinson P, Joubert G, Barron A, Grant D, Paradis K, Seidman E, Wall W, Rosenberg H, Howard J, Williams S, Stiller C . Hypertrophic cardiomyopahty associated with taclolimus in peadiatric transplant patients. Lancet 345: 894–896 ( 1995)
Evans DA, Skalder SW, Jones TK, Clardy J, Stout TJ . Total synthesis of the macrolide antibiotic cytovaricin. J Am Chem Soc 112: 7001–7031 ( 1990)
Kurosawa K, Takahashi K, Tsuda E . SNF4435C and D, novel immunosuppressants produced by a strain of Streptomyces spectabilis. I. Taxonomy, fermentation, isolation and biological activities. J Antibiot 54: 541–547 ( 2001)
Nakagawa A, Miura S, Imai H, Imamura N, Omura S . Structure and biosynthesis of a new antifungal antibiotic, phthoramycin. J Antibiot 42: 1324–1327 ( 1989)
Hirota A, Okada H, Kanza T, Nakayama M, Hirota H, Isogai A . Structure of kaimonolide A, a novel macrolide plant growth inhibitor from a Streptomyces strain. Agric Biol Chem 53: 2831–2833 ( 1989)
Kihara T, Kusakabe H, Nakamura G, Sakurai T, Isono K . Cytovaricin, a novel antibiotic. J Antibiot 34: 1073–1074 ( 1981)
Laatsch H, Kellner M, Wolf G, Lee YS, Hansske F, Konetschny-Rapp S, Pessara U, Scheuer W, Stockinger H . Oligomycin F, a new immunosuppressive homologue of oligomycin A. J Antibiot 46: 1334–1341 ( 1993)
Kim HS, Han SB, Kim HM, Kim YH, Lee JJ . 41-Demethylhomooligomycin B, a new immunosuppresant antibiotic from Streptomyces ostreogriseus. J Antibiot 49: 1275–1277 ( 1996)
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Takahashi, K., Yoshihara, T. & Kurosawa, K. Ushikulides A and B, Immunosuppressants Produced by a Strain of Streptomyces sp.. J Antibiot 58, 420–424 (2005). https://doi.org/10.1038/ja.2005.55
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DOI: https://doi.org/10.1038/ja.2005.55
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