Abstract
Nafuredin, a δ-lactone antibiotic, is a fungal metabolite showing selective helminth NADH-fumarate reductase inhibition, and whose target had been revealed as complex I. We found that nafuredin is easily converted to nafuredin-γ by weak alkaline treatment. The structure of nafuredin-γ was elucidated as a γ-lactone form of nafuredin with keto-enol tautomerism. Nafuredin-γ shows similar complex I inhibitory activity as nafuredin, and it also possesses anthelmintic activity in vivo.
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Shiomi, K., Ui, H., Suzuki, H. et al. A γ-Lactone Form Nafuredin, Nafuredin-γ, also Inhibits Helminth Complex I. J Antibiot 58, 50–55 (2005). https://doi.org/10.1038/ja.2005.5
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DOI: https://doi.org/10.1038/ja.2005.5
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