Abstract
Glucose-regulated protein 78 (GRP78) resides in endoplasmic reticulum (ER) and plays a role in protecting tumor cells against the toxic effects of anticancer agents. During the search for down-regulators of GRP78 using a reporter gene (luciferase) assay system, we isolated a novel compound designated as deoxyverrucosidin (1), a congener of verrucosidin (2), from Penicillium sp. and identified it as a down-regulator of the grp78 gene. The structure of 1 was determined by mainly ESI-mass and two-dimensional NMR spectra. 1 dose-dependently inhibited the expression of GRP78 promoter with an IC50 of 30 nM.
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Choo, SJ., Park, HR., Ryoo, IJ. et al. Deoxyverrucosidin, a Novel GRP78/BiP Down-regulator, Produced by Penicillium sp.. J Antibiot 58, 210–213 (2005). https://doi.org/10.1038/ja.2005.26
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DOI: https://doi.org/10.1038/ja.2005.26
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