Abstract
The complex species Mus musculus is widespread in Eurasia and consists of four parapatric genetical entities (subspecies) that have recently radiated. Two of them (M. m. domesticus and M. m. musculus) are known to interact through a narrow zone of hybridisation across which autosomal and mitochondrial exchanges are very limited and Y chromosome exchange is absent. We extend here the study of this group by the genetical analysis of 22 Asian strains of various origins (China, Korea, Japan, Taiwan, Philippines and Indonesia). A survey of protein variation at ten polymorphic loci confirmed that these animals belong to either the subspecies M. m. musculus (northern type in Asia, ranging westwards to Eastern Europe) or to M. m. castaneus (southern Asian type) and revealed a certain degree of intergradation between the two taxa. Y chromosome variations were assessed in these strains using a Y specific DNA probe representing part of a small multigene family and also in four M. m. domesticus (the Western European house mouse) strains of various origins and one M. m. bactrianus (from Pakistan). Musculus and castaneus were identically monomorphic for one type of organisation of this Y repeated family, while domesticus and bactrianus were very similar to each other, showing slightly different types of organisation. Introgression of a bactrianus Y chromosome into the territory of castaneus was found in Indonesia. The present distribution of the Y types among the four subspecies is not phylogenetically concordant with the known distributions of autosomal and mitochondrial variants. The possible role of reticulation to account for this is discussed. The repeated family is organised in a limited number of subfamilies that characterise each of our Y types, indicating that a mechanism of concerted evolution underlies its recent evolution in Mus musculus.
Similar content being viewed by others
Article PDF
References
Bishop, C E. Boursot, P. Baron, B. Bonhomme, F, and Hatat, D. 1985. Most classical Mus musculus domesticus laboratory strains carry a Mus musculus musculus Y chromosome, Nature (London), 315, 70–72.
Bishop, C E, and Hatat, D. 1987. Molecular cloning and sequence analysis of a mouse Y chromosome RNA transcript expressed in the testis. Nucleic Acids Res, 15 (7), 2959–2969.
Bishop, C E. Roberts, C. Michot, J L. Nagamine, C. Winking, H. Guenet, J-L, and Weith, A. 1987. The Use of specific DNA probes to analyse the Sxr mutation in the mouse. In Goodfellow, P. N., Craig, I. W., Smith, J. C. and Wolfe, J. (eds) The Mammalian Y Chromosome: Molecular Search for the Sex-Determining Factor, The Company of Biologists Limited, Cambridge, pp. 167–175.
Bonhomme, F. 1986a. Evolutionary relationships in the Genus Mus, In Potter, M., Nadeau, J. H. and Cancro, M. P. (eds) The Wild Mouse in Immunology, Springer-Verlag Publisher, pp. 19–34.
Bonhomme, F. 1986b. Molecules, populations and species evolution in the Genus Mus (Mammalia: Rodentia). In Iwatsuki, K., Raven, P. H. and Bock, W. (eds) Modern Aspects of the Species, University of Tokyo Press, pp. 125–143.
Bonhomme, F. Catalan, J. Britton-Davidian, J. Chapman, V M. Moriwaki, K. Nevo, E, and Thaler, L. 1984. Biochemical diversity and evolution in the Genus Mus.. Biochem Genet, 22, 275–303.
Bonhomme, F. Miyashita, N. Boursot, P. Catalan, J, and Moriwaki, K. 1989. Genetical variation and polyphyletic origin in Japanese Mus musculus. Heredity, 63, 299–308.
Boursot, P. Bonhomme, F. Britton-Davidian, J. Catalan, J. Yonekawa, H. Orsini, P. Gerasimov, S, and Thaler, L. 1984. Introgression différentielle des génomes nucléaires et mitochondriaux chez deux semiespèces européennes de souris. C R Acad Sci, Ser III, 299, 691–693.
Delarbre, C. Kashi, Y. Boursot, P. Beckman, J S. Kourilsky, P. Bonhomme, F, and Gachelin, G. 1988. Phylogenetic distribution in the genus Mus of t-complex specific DNA and protein markers: inferences on the origin of t-haplotypes. Mol Biol Evol, 5 (2), 120–133.
Dover, G. 1982. Molecular drive: a cohesive mode of species evolution. Nature, 299, 111–117.
Feinberg, A P, and Vogelstein, B. 1983. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem, 132, 6–13.
Ferris, S D. Sage, R D. Huang, C M. Nielsen, J T. Ritte, E, and Wilson, A C. 1983. Flow of mitochondrial DNA across a species boundary. Proc Natl Acad Sci USA, 80, 2290–2294.
Gyllensten, U, and Wilson, A C. 1987. Interspecific mitochondrial DNA transfer and the colonization of Scandinavia by mice. Genet Res Camb, 49, 25–29.
Hunt, W G, and Selander, R K. 1973. Biochemical genetics of hybridisation in European house mouse. Heredity, 31, 11–33.
Miyashita, N. Moriwaki, K. Minezawa, M. Yonekawa, H. Bonhomme, F. Migita, S. Yu, Z-C. Lu, D Y. Cho, O S, and Tohari, M. 1985. Allelic constitution of the hemoglobin beta chain in wild populations of the house mouse, Mus musculus. Biochem Genet, 23, (11–12), 975–986.
Moriwaki, K. 1986. Genetic features of major geographic isolates of Mus musculus, In Potter, M., Nadeau, J. H. and Cancro, M. P. (eds) The Wild Mouse in Immunology, Springer-Verlag Publisher, pp. 55–67.
Nishioka, Y, and Lamothe, E. 1987. Evolution of a mouse Y chromosomal sequence flanked by highly repetitive elements. Genome, 29, 380–383.
Potter, M. 1986. Listing of stocks and strains of mice in the genus Mus derived from the feral state. In Potter, M., Nadeau, J. H. and Cancro, M. P. (eds) The Wild Mouse in Immunology, Springer-Verlag Publisher, pp. 373–395.
Sage, R D. Whitney, J B, and Wilson, A C. 1986. Genetical analysis of a hybrid zone between domesticus and musculus mice (Mus musculus complex): hemoglobin polymorphisms, In Potter, M., Nadeau, J. H. and Cancro, M. P. (eds) The Wild Mouse in Immunology, Springer-Verlag Publisher, pp. 75–85.
Silver, L M. Hammer, M. Fox, H. Garrels, J. Bucan, M. Herrmann, B. Frischauf, A M. Lehrach, H. Winking, H. Figueroa, F, and Klein, J. 1987. Molecular evidence for the rapid propagation of mouse t haplotypes from a single, recent, ancestral chromosome. Mol Biol Evol 4 (5), 473–482.
Suzuki, H. Miyashita, N. Moriwaki, K. Kominami, R. Muramatsu, M. Kanehisa, T. Bonhomme, F. Petras, M L. Yu, Z-C, and Lu, D-Y. 1985. Evolutionary implication of heterogeneity of nontranscribed spacer region of ribosomal DNA repeating units in various subspecies of Mus musculus. Mol Biol Evol, 3, 126–137.
Vanlerberghe, F. Dod, B. Boursot, P. Bellis, M, and Bonhomme, F. 1986. Absence of Y chromosome introgression across the hybrid zone between Mus musculus domesticus and Mus musculus musculus. Genet Res Camb, 48, 191–297.
Vanlerberghe, F. Boursot, P. Catalan, J. Gerasimov, S. Bonhomme, F. Botev, A, and Thaler, L. 1988a. Analyse génétique de la zone d'hybridation entre les deux sous-espèces de souris Mus musculus domesticus et Mus musculus musculus en Bulgarie. Genome, 30, 427–437.
Vanlerberghe, F. Boursot, P. Nielsen, J T, and Bonhomme, F. 1988b. A steep cline for mitochondrial DNA in Danish mice. Genet Res Camb, 52, 185–193.
Yonekawa, H. Moriwaki, K. Gotoh, O. Hayashi, J-L. Watanabe, J. Miyashita, N. Petras, M L, and Tagashira, Y. 1981. Evolutionary relationships among five subspecies of Mus musculus based on restriction enzyme cleavage patterns of mitochondrial DNA Genetics, 98, 801–816.
Yonekawa, H. Gotoh, O. Tagashira, Y. Matsushima, Y. Shi, L-L. Cho, W S. Miyashita, N, and Moriwaki, K. 1986. A hybrid origin of Japanese mice “Mus musculus molossinus”, In Potter, M., Nadeau, J. H. and Cancro, M. P. (eds) The Wild Mouse in Immunology, Springer Verlag Publisher, pp. 62–67.
Yonekawa, H. Moriwaki, K. Gotoh, O. Miyashita, N. Matsushima, Y. Shi, L. Cho, W S. Zhen, X-L, and Tagashira, Y. 1988. Hybrid origin of Japanese mice “Mus musculus molossinus” evidence from restriction analysis of mitochondrial DNA. Mol Biol Evol, 5 (1) 63–78.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Boursot, P., Bonhomme, F., Catalan, J. et al. Variations of a Y chromosome repeated sequence across subspecies of Mus musculus. Heredity 63, 289–297 (1989). https://doi.org/10.1038/hdy.1989.101
Received:
Issue Date:
DOI: https://doi.org/10.1038/hdy.1989.101
This article is cited by
-
Discovery of a new HBB haplotype w2 in a wild-derived house mouse, Mus musculus
Mammalian Genome (2008)
-
The identification of Y Chromosome-linked markers with random sequence oligonucleotide primers
Mammalian Genome (1993)
-
The musculus-type Y Chromosome of the laboratory mouse is of Asian origin
Mammalian Genome (1992)
-
Mouse Y Chromosome
Mammalian Genome (1992)
-
Genetical variation and polyphyletic origin in Japanese Mus musculus
Heredity (1989)