Abstract
The detoxification of both ethanol and isopropanol in relation to the Adh locus was studied in the “Lagar de los Reyes” (LR) lines of Drosophila melanogaster. Homozygous lines for the AdhF and the Adhs alleles were kept on an ethanol-supplemented medium for about 60 generations. After the selection, adult flies from these selected lines (LRSeF and LRSeS) were tested for utilisation of, and tolerance to, ethanol and isopropanol, and compared with appropriate controls (LRCF and LRCS) kept on regular medium. Both LRC and LRSe were able to use ethanol (but not isopropanol) as food, the selected flies showing a larger utilisation range than controls. Independently of the lines, FF flies showed a higher or equal ethanol and isopropanol tolerance than SS animals, the females being more or equally tolerant compared with the males. Increased tolerance to ethanol (but not to isopropanol detoxification is equally tolerant compared with the males. Increased tolerance to ethanol (but not to isopropanol) was found in the selected lines. Because of this, a partial independence of ethanol and isoproponal detoxification is suggested.
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Sánchez-Cañete, F., Dorado, G. & Barbancho, M. Ethanol and Isopropanol detoxification associated with the Adh locus of Drosophila melanogaster. Heredity 56, 167–175 (1986). https://doi.org/10.1038/hdy.1986.28
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DOI: https://doi.org/10.1038/hdy.1986.28
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