Summary
The a priori theoretical distribution of marker-linked quantitative effects in crosses involving inbred lines, and the number of quantitative loci contributing to such effects was obtained by numerical analysis, and examined as a function of the number and effects of the quantitative loci differentiating the lines, the location of the marker relative to the chromosome ends, and the mapping function. Over a wide range of assumptions it was found that the probability that a given marker will have an associated linked quantitative effect equal in magnitude to 0·2 phenotypic standard deviations or greater is of the order of 0·10 or more. In most of these cases it can be expected that the marker-linked effects will be due to one, or at the most two, quantitative loci in the vicinity of the marker.
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Soller, M., Brody, T. & Genizi, A. The expected distribution of marker-linked quantitative effects in crosses between inbred lines. Heredity 43, 179–190 (1979). https://doi.org/10.1038/hdy.1979.73
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DOI: https://doi.org/10.1038/hdy.1979.73
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