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Progress and prospects: Biological properties and technological advances of herpes simplex virus type 1-based amplicon vectors

Gene Therapy volume 16, pages 709–715 (2009)Cite this article

Abstract

The last two years have seen significant advances in our understanding of the cellular innate responses elicited or activated by the entry of amplicon particles, which may, in part, explain the transient nature of transgene expression often observed in cells infected with helper-free amplicon stocks. At the technological level, the most consistent progress has been in strategies to enhance the stability of transgene cassettes, either through integration into host chromosomes or through the conversion of the amplicon genome into a replication-competent extrachromosomal element.

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Authors and Affiliations

  1. Université de Lyon, Lyon, France; Université Lyon 1, Lyon, France

    A L Epstein

  2. CNRS, UMR5534, Centre de Génétique Moléculaire et Cellulaire, Université Claude Bernard Lyon, Villeurbanne, France

    A L Epstein

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  1. A L Epstein
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Correspondence to A L Epstein.

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Epstein, A. Progress and prospects: Biological properties and technological advances of herpes simplex virus type 1-based amplicon vectors. Gene Ther 16, 709–715 (2009). https://doi.org/10.1038/gt.2009.42

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