Abstract
Purpose To determine the abundance and variety of participate debris in new generation hydroxypropyl methylcellulose (HPMC) samples.
Method Three samples of sterile HPMC-Ophtal H were examined using a confocal laser scanning microscope, scanning electron microscope and mass spectrometry.
Results Confocal laser scanning microscopy of the samples showed that particulate matter in HPMC was less than 30 (µm in size and at a density of less than 1000 particles per millilitre. No discernible details were seen by the scanning electron microscope, and mass spectrometry did not identify any bands.
Conclusion Improved methods of preparation including filtration may be responsible for decreased particulate debris in new generation HPMC.
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Ray-Chaudhuri, N., Jayamanne, D. & Strong, N. New generation hydroxypropyl methylcellulose (HPMC-Ophtal H) for intraocular surgery: A confocal laser scanning microscopy study. Eye 12, 723–724 (1998). https://doi.org/10.1038/eye.1998.176
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DOI: https://doi.org/10.1038/eye.1998.176