Abstract
Diclofenac is a non-steroidal anti-inflammatory drug available in an ophthalmic preparation. We present a prospective randomised double-masked placebo-controlled trial involving 40 patients that assessed the effectiveness of topical dicIofenac in relieving pain from traumatic corneal abrasions. Statistical analysis of visual analogue and categorical pain scores revealed a significant reduction in pain experienced by subjects in the diclofenac group (p<0.02).
Similar content being viewed by others
Article PDF
References
Sher NA, Frantz JM, Talley A, et al. Topical diclofenac in the treatment of ocular pain after excimer photo-refractive keratectomy. Refract Corneal Surg 1993;9:425–36.
Dua HS, Forrester JV . The corneoscleral limbus in human corneal epithelial wound healing. Am J Ophthalmol 1990;110:646–56.
Yang Z, Zhao Z, Panjwani N . Gangliosides of migrating and nonmigrating corneal epithelium in organ and cell culture. Invest Ophthalmol Vis Sci 1996;37:501–10.
Ku EC, Lee W, Kothari HV, Scholer DW . Effect of diclofenac sodium on the arachiodonic acid cascade. Am J Med 1986;80(Suppl):18–23.
Hulbert MFG . Efficacy of eye pad in corneal healing after corneal foreign body removal. Lancet 1991;337:643.
Kantor TG . Current modalities in arthritic disease. Am J Med 1987;83(Suppl 4B):2–5.
Loya N, Bassage S, Vyas S, Del Cerro M, Park SB, Aquavella JV . Topical diclofenac following excimer laser: effects on corneal sensitivity and wound healing in rabbits. J Refract Corneal Surg 1994;10:423–7.
Tripathi BJ, Tripathi RC, Kolli P . Cytotoxicity of ophthalmic preservatives on human corneal epithelium. Lens Eye Toxicity Res 1992;9:361–75.
Bazan HEP . The synthesis and effects of eicosanoids in avascular ocular tissues. In: Bito LZ, Stjernschantz J, editors. The ocular effects of prostaglandins and other eicosanoids. New York: AR Liss, 1989:73–84.
Scholer DW, Ku EC, Boettcher I, Schweizer A . Pharmacology of diclofenac sodium. Am J Med 1986;80(Suppl):34–8.
Martini A, Bondiolotti GP, Sacerdote P, et al. Diclofenac increases beta-endorphin plasma concentrations. J Int Med Res 1984;12:92–5.
Bauerman RW, McDonald MB, Varnell RJ, Thompson HW . Neurophysiological evaluation of corneal nerves in rabbits following excimer PRK [abstract]. Invest Ophthalmol Vis Sci 1993;34:704.
Huskisson EC . Measurement of pain. Lancet 1974;2:1127–31.
Aitken RCB . Measurement of feelings using analog scales. Proc R Soc Med 1969;62:989–92.
Scolville B, Krieglstein GK, Then E, Yokoyama S, Yokoyama T . Measuring drug-induced eye irritation: a simple assay. J Clin Pharmacol 1985;25:210–8.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jayamanne, D., Fitt, A., Dayan, M. et al. The effectiveness of topical diclofenac in relieving discomfort following traumatic corneal abrasions. Eye 11, 79–83 (1997). https://doi.org/10.1038/eye.1997.15
Issue Date:
DOI: https://doi.org/10.1038/eye.1997.15
Keywords
This article is cited by
-
Efficacy and safety of bromfenac for the treatment of corneal ulcer pain
Advances in Therapy (2010)