Abstract
This study investigated the effect of pretreatment with topical diclofenac 0.1% on the changes in intraocular pressure (IOP) associated with use of an external ocular compression device. The IOP reduction in eyes receiving pretreatment was significantly greater than in controls after 40 minutes of compression, and the recovery in IOP after removal of the compression device was significantly reduced. We conclude that the IOP rise after such compression is largely prostaglandin mediated, and suggest that use of ocular compression devices is associated with marked intraocular prostaglandin release.
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References
Moseley M, Thompson JR, et al. Comparison of the Keeler Pulsair 200 non-contact tonometer with Goldmann applanation. Eye 1993; 7: 127–30.
Ropo A, Ruusuvaara P, et al. Effect of ocular compression on intraocular pressure in periocular anaesthesia. Acta Ophthalmol (Copenh) 1990; 68: 227–9.
Feneck RO, Durkin MA . A comparison between the effects of fentanyl, droperidol with fentanyl and halothane anaesthesia on intraocular pressure in adults. Anaesthesia 1987; 42: 266–9.
Jay WM, Aziz MZ, Green K . Effect of digital massage on intraocular pressure and ocular and optic nerve blood flow. Acta Ophthalmol (Copenh) 1986; 64: 58–62.
Boiling JP, Kurrie RW, O'Day DM . Effect of ocular compression on intraocular pressure. Ophthalmic Surg 1985; 16: 563–65.
Constable PH, Porter EJB . Extraocular compression prior to cataract surgery: time course of reduction and subsequent recovery of intraocular pressure. Eye 1993; 7: 731–4.
Ambache N, Kavanagh L, Whiting J . Effect of mechanical stimulation on rabbits' eyes: release of active substances in anterior chamber perfusates. J Physiol (Lond) 1965; 176: 378–408.
Ambache N, Brummer HC . A simple chemical procedure for distinguishing E from F prostaglandins, with application to tissue extracts. Br J Pharmacol 1969; 33: 162–70.
Starr MS . Further studies on the effect of prostaglandin on intraocular pressure in the rabbit. Exp Eye Res 1971; 11: 170–7.
Nuefeld AH, Sears ML . The site of action of prostaglandin E2 on the disruption of the blood-aqueous barrier in the rabbit eye. Exp Eye Res 1973; 17: 445–8.
Green K . Permeability properties of the ciliary epithelium in response to prostaglandins. Invest Ophthalmol 1973; 12: 752–8.
Bhattacherjee P, Eakins KE . Inhibition of the prostaglandin synthetase systems in ocular tissues by indomethacin. Br J Pharmacol 1974; 50: 227–30.
Miller JD, Eakins KE, Atwal M . The release of PGE2 like activity into aqueous humour after paracentesis and its prevention by aspirin. Invest Ophthalmol 1973; 12: 939–42.
Obstbaum SA, Podos MD . Ocular compression and non-corticosteroidal anti-inflammatory agents. Am J Ophthalmol 1975; 79: 1008–11.
Goa KL, Chrisp P . Ocular diclofenac. Drugs Ageing 1992; 2: 473–86.
Rowland JM, Ford JF, et al. Effect of topical diclofenac sodium in a rabbit model of ocular inflammation and leukotaxis. J Ocular Pharmacol 1986; 2: 23–9.
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Constable, P., Adams, G. Use of topical diclofenac in association with external ocular compression. Eye 8, 462–464 (1994). https://doi.org/10.1038/eye.1994.109
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DOI: https://doi.org/10.1038/eye.1994.109