Abstract
Studies of the effect of visual deprivation on cells in the lateral geniculate nucleus (LGN) show that there are two distinct sensitive periods in the monkey during which different reactions between the visual pathways related to the two eyes predominate and requirements for recovery from deprivation differ. The first extends from birth to about 8 weeks of age. The main interaction between the pathways from the two eyes is competitive, segregation of cortical ocular dominance columns occurs during this early period and monocular deprivation results initially in hypertrophy of undeprived LGN cells, with later parallel shrinkage of both deprived and undeprived par-vocellular cells. Simply reopening the closed eye produces no recovery but reverse suture is effective in reversing some of the changes. The second sensitive period starts from about 8 weeks of age, although the peak of the later sensitivity appears to be at 7-9 months of age and some effect is still present at 12-18 months. During this later phase a cooperative interaction between the pathways related to the two eyes is necessary for normal development and in the absence of this selective shrinkage of both deprived and undeprived parvocellular LGN cells occurs. Simply reopening an eye during this late sensitive period allows recovery of these cells to normal size.
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Von Noorden GK . Amblyopia: a multidisciplinary approach. Invest Ophthalmol Vis Sci 1985;26:1704–16.
Fells P . Amblyopia: an historical perspective. Eye 1990;4:775–86.
Wiesel TN, Hubel DH . Effects of visual deprivation on morphology and physiology of cells in the cat's lateral geniculate body. J Neurophysiol 1963;26:978–93.
Wiesel TN, Hubel DH . Single cell responses in striate cortex of kittens deprived of vision in one eye. J Neurophysiol 1963;26:1003–17.
Wiesel TN, Hubel DH . Comparison of the effects of unilateral and bilateral eye closure on cortical responses in kittens. J Neurophysiol 1965;28:1029–40.
Guillery RW . The effect of lid suture upon the growth of cells in the dorsal lateral geniculate nucleus in kittens. J Comp Neurol 1973; 148:417–22.
Guillery RW, Stelzner DJ . The differential effects of unilateral lid closure upon the monocular and binocular segments of the dorsal lateral geniculate nucleus in the cat. J Comp Neurol 1970;139:413–22.
Guillery RW . Binocular competition in the control of geniculate cell growth. J Comp Neurol 1972;144:117–30.
Headon MP, Powell TPS . Cellular changes in the lateral geniculate nucleus of infant monkeys after suture of the eyelids. J Anat 1973;116:135–45.
Von Noorden GK . Experimental amblyopia in monkeys: further behavioral observations and clinical correlations. Invest Ophthalmol 1973;12:721–6.
Von Noorden GK . Histological studies of the visual system in monkeys with experimental amblyopia. Invest Ophthalmol Vis Sci 1973; 12:727–38.
Hubel DH, Wiesel TN, LeVay S . Plasticity of ocular dominance columns in monkey striate cortex. Phil Trans R Soc [B] 1977;278:377–409.
LeVay S, Wiesel TN, Hubel DH . The development of ocular dominance columns in normal and visually deprived monkeys. J Comp Neurol 1980;191:1–51.
Vital-Durand F, Garey LJ, Blakemore C . Monocular and binocular deprivation in the monkey: morphological effects and reversibility. Brain Res 1978;158:45–64.
Headon MP, Sloper JJ, Hiorns RW, Powell TPS . Sizes of neurons in the primate lateral geniculate nucleus during normal development. Dev Brain Res 1985;18:51–6.
Headon MP, Sloper JJ, Hiorns RW, Powell TPS . Effects of monocular closure at different ages on deprived and undeprived cells in the primate lateral geniculate nucleus. Dev Brain Res 1985;18:57–78.
Von Noorden GK, Crawford MLJ, Middleditch PR . The effects of monocular visual deprivation: disuse or binocular interaction? Brain Res 1976;111:277–85.
Swindale NV, Vital-Durand F, Blakemore C . Recovery from monocular deprivation in the monkey. III. Reversal of anatomical effects in the visual cortex. Proc R Soc [B] 1981;213:435–50.
Headon MP, Sloper JJ, Hiorns RW, Powell TPS . Cell size changes in undeprived laminae of the monkey lateral geniculate nucleus after monocular closure. Nature 1979;281:572–4.
Headon MP, Sloper JJ, Hiorns RW, Powell TPS . Shrinkage of cells in undeprived laminae of the monkey lateral geniculate nucleus following late closure of one eye. Brain Res 1981;229:187–92.
Sloper JJ, Headon MP, Powell TPS . Effects of enucleation at different ages on the sizes of neurons in the lateral geniculate nucleus of infant and adult monkeys. Dev Brain Res 1987;31:259–65.
Sloper JJ, Headon MP, Powell TPS . Changes in the size of cells in the monocular segment of the primate lateral geniculate nucleus during normal development and following visual deprivation. Dev Brain Res 1987;31:267–76.
Blakemore C, Garey LJ, Vital-Durand F . The physiological effects of monocular deprivation and their reversal in the monkey's visual cortex. J Physiol (Lond) 1978;283:223–62.
Horton JC . Cytochrome oxidase patches: a new cytoarchitectonic feature of monkey visual cortex. Phil Trans R Soc [B] 1984;304:199–254.
Von Noorden GK, Crawford MLJ . Morphological and physiological changes in the monkey visual system after short term lid suture. Invest Ophthalmol Vis Sci 1978;17:762–8.
Garey LJ, Vital-Durand F . Recovery from monocular deprivation in the monkey. II. Reversal of morphological effects in the lateral geniculate nucleus. Proc R Soc [B] 1981;213:425–33.
Headon MP, Sloper JJ, Hiorns RW, Powell TPS . Effect of reopening an eye after a period of monocular deprivation on sizes of neurons in the primate lateral geniculate nucleus. Dev Brain Res 1985;18:57–78.
Blakemore C, Vital-Durand F, Garey LJ . Recovery from monocular deprivation in the monkey. I. Reversal of physiological effects in the visual cortex. Proc R Soc [B] 1981;213:399–423.
Sloper JJ, Headon MP, Powell TPS . Simultaneous hypertrophy of cells related to each eye in the lateral geniculate nucleus of the infant monkey following short term reverse suture. Dev Brain Res 1984;15:295–7.
Sloper JJ, Headon MP, Powell TPS . Experiments to study recovery of LGN cell size following lid closure and reverse suture in infant monkeys. Dev Brain Res 1988;40:47–59.
Murphy KM, Mitchell DE . Reduced visual acuity in both eyes of monocularly deprived kittens following a short or long period of reverse occlusion. J Neurosci 1987;7:1526–36.
Cynader M . Prolonged sensitivity to monocular deprivation in dark-reared cats: effects of age and visual exposure. Dev Brain Res 1983;8:155–64.
Boothe RG, Dobson V, Teller DY . Postnatal development of vision in human and non-human primates. Annu Rev Neurosci 1985;8:495–545.
Hickey TL . Postnatal development of the human lateral geniculate nucleus: relationship to a critical period for the visual system. Science 1977;198:836–8.
Garey LJ, Saini KD . Golgi studies of the normal development of neurons in the lateral geniculate nucleus of the monkey. Exp Brain Res 1981;44:117–28.
De Courten C, Garey LJ . Morphology of neurons in the human lateral geniculate nucleus and their normal development. Exp Brain Res 1982;47:159–71.
Horton JC, Hedley-White ET . Mapping of cytochrome oxidase patches and ocular dominance columns in the human visual cortex. Phil Trans R Soc [B] 1984;304:255–272.
Banks MS, Aslin RN, Letson RD . Sensitive period for the development of human binocular vision. Science 1975;190:675–7.
Hohmann A, Creutzfeldt OD . Squint and the development of binocularity in humans. Nature 1975;254:613–4.
Ing MR . Early surgical alignment for congenital esotropia. J Paediatr Ophthalmol Strabismus 1983;20:11–8.
Vaegan Taylor D . Critical period for deprivation amblyopia in children. Trans Ophthalmol Soc UK 1979;99:432–9.
Atkinson J . Early visual development: differential functioning of parvocellular and magnocellular pathways. Eye 1992;6:129–35.
Elston JS, Timms C . Clinical evidence for the onset of the sensitive period in infancy. Br J Ophthalmol 1992;76: 327–8.
Hubel DH, Wiesel TN . The period of susceptibility to the physiological effects of unilateral eye closure in kittens. J Physiol 1970;206:419–36.
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Sloper, J. Competition and cooperation in visual development. Eye 7, 319–331 (1993). https://doi.org/10.1038/eye.1993.70
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DOI: https://doi.org/10.1038/eye.1993.70
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