Abstract
Teratology is most simply defined as “the study of environmental agents which disturb development”. A more comprehensive definition is “the study of causes, mechanisms, and manifestations of developmental deviation, structural or functional.” Teratology has several important purposes. Obviously, the most important is to protect future generations by identifying environmental agents that cause malformations. In this sphere, ophthalmologists are generally not the primary detectors. One notable exception is when Gregg, in 1941, recognised that an increase in congenital cataracts was due to a viral agent and brought rubella embryopathy to the attention of the medical community.1 Another pertinent reason for teratology is that it gives us insights into normal development. As Harvey said with such flair, “nature is nowhere accustomed more openly to display her secret mysteries than in cases where she shows tracings of her workings apart from the beaten path”.2
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Gregg NM : Congenital cataract following German measles in the mother. Trans Ophthalmol Soc Aust 1941, 3: 35–45.
McKusick WV : Forward. In Gorlin RJ, Pindborg JJ (eds): Syndromes of the Head and Neck. New York: McGraw-Hill, 1964.
Wilson JG : Current status of teratology, in Wilson JG and Fraser FC (eds): In Handbook of Teratology: General Principles and Etiology, vol. 1, 1977.
Fraser FC : Evolution of a palatable multifactorial threshold model. Am J Hum Genet 1980, 32: 796–813.
Miller MT and Stromland K : Ocular motility in thalidomide embryopathy. J Pediatr Ophthalmol Strabismus 1991, 28: 47–54.
Miller MT : Thalidomide embryopathy: A model for the study of congenital incomitant horizontal strabismus. Tr Am Ophthalmo Soc 1991, 89: 623–674.
Hotchkiss MG, Miller NR, Clark AW, Green WR : Bilateral Duane's retraction syndrome: a clinical pathologic case report. Arch Ophthalmol 1980, 98: 870.
Hoyt WF, Nachtigaller I : Anomalies of ocular motor nerves: neuroanatomic correlations of paradoxical innervation in Duane syndrome and related congenital ocular motor diseases. Am J Ophthalmol 1965, 60: 443–448.
Miller NR, Kiel SM, Green WR, et al: Unilateral Duane's retraction syndrome (type 1). Arch Ophthalmol 1982, 100: 1468–1472.
Papst W : Thalidomid und kongenitale Anomalien der Augen. Bericht Deutsch Ophthal Ges 1964, 65: 209–215.
Stromland K, Miller MT, Cook C : Ocular teratology. Surv Ophthalmol 1991, 35: 429–446.
Stromland K : Ocular abnormalities in the fetal alcohol syndrome. Ada Ophthalmol 1985, 63(Suppl): 171.
Miller MT, Epstein R, Sugar J, Pinchoff B, Sugar A, Gammon JA, Mittelman D, Dennis R, Israel J : Anterior segment anomalies associated with fetal alcohol syndrome. J Pediatr Ophthalmol Strabismus 1984, 21: 8–18.
Reese AB and Ellsworth RM : Observations on the development of the anterior chamber angle with reference to the pathogenesis of congenital glaucoma. Am J Ophthalmol 1979, 88: 424.
Waring GO, Rodrigues MM, Laibson PR : Anterior chamber cleavage syndrome: A stepladder classification. Surv Ophthalmol 1975, 30: 30.
Cook SC and Sulik KK : Keratolenticular dysgenesis (Peter's anomaly) as a result of acute embryonic insult during gastrulation. J Pediatr Ophthalmol Strabismus 1988, 25: 60–66.
Cook CS, Nowotny AZ, Sulik KK : Fetal alcohol syndrome: Eye malformations in a mouse model. Arch Ophthalmol 1987, 105: 1576–81.
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Miller, M. Ocular teratology. Eye 6, 177–180 (1992). https://doi.org/10.1038/eye.1992.35
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DOI: https://doi.org/10.1038/eye.1992.35