Abstract
A review is given of lid-suture myopia in monkeys, of the natural lower field myopia in the pigeon eye, and of myopias in chick eyes produced by visual occluders. The ametropias produced by ophthalmic lenses, and the pharmacology of experimental myopia, are reviewed. Human studies are reviewed which can be taken as models of the experimental myopias. Two theories of myopic growth are outlined and evaluated.
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Duke-Elder Sir W. Stewart . Text-book of Ophthalmology. Vol IV. London, Henry Kimpton. 1949.
Duke-Elder Sir Stewart and Abrams D . System of Ophthalmology Vol V London, Henry Kimpton. 1970.
Blach Rolf K . Degenerative Myopia. In Krill AE and Archer DB Eds. Krill's Hereditary Retinal and Choroidal Diseases Vol II. Hagerstown, Harper and Row. 1977: 911–937.
Curtin Brian J . The Myopias: Basic Science and Clinical Management. Philadelphia, Harper and Row. 1985.
Wiesel TN, and Raviola E . Myopia and Eye enlargement after neonatal lid fusion in monkeys. Nature 1977; 266: 66–8.
Heine L . Beitrage zur anatomie des myopischen Auges. Arch Augenheilk 1899; 38: 277–90.
Raviola E, and Wiesel TN . Effect or dark-rearing on experimental myopia in monkeys. Invest Ophthalmol Vis Sci 1978; 17: 485–8.
Wiesel TN and Raviola E . Increase in axial length of the macaque monkey eye after corneal opacification. Invest Ophthalmol Vis Sci 1979; 18: 1232–6.
Raviola E, and Wiesel TN . An animal model of myopia. New Eng J Med 1985; 312: 1609–15.
Guyton DL, Greene PR, Scholz RT . Dark-rearing interference with emmetropisation in the rhesus monkey. Invest Ophthalmol Vis Sci 1988; 29: (suppl) 33.
von Noorden GK and Crawford MLJ . Lid-closure and refractive error in macaque monkeys. Nature 1978; 272: 53–4.
Smith EL, Harwerth RS, Crawford MLJ, von Noorden GK . Observations on the effects of form deprivation on the refractive status of the monkey. Invest Ophthalmol Vis Sci 1987; 28: 1236–45.
Yinon U . Myopia induction in animals following alteration of the visual input during development: a review. Curr Eye Res 1984; 3: 677–90.
Fitzke FW, Hayes BP, Hodos W, Holden AL . Electrophysiological optometry using Schemer's principle in the pigeon eye. J Physiol 1985; 369: 17–31.
Fitzke FW, Hayes BP, Hodos W, Holden AL, Low JC . Refractive sectors in the visual field of the pigeon eye. J Physiol 1985; 369: 33–44.
Hodos W, Fitzke FW, Hayes BP, Holden AL . Experimental myopia in chicks: ocular refraction by electroretinography. Invest Ophthalmol Vis Sci 1985; 26: 1423–30.
Hayes BP, Fitzke FW, Hodos W, Holden AL . A morphological analysis of experimental myopia in young chickens. Invest Ophthalmol Vis Sci 1986; 27: 981–91.
Pumphrey RJ . Sensory Organs: Vision in Marshall AJ. (Ed) Biology and Comparative Physiology of Birds. New York. Academic Press: 1961.
Hayes BP . The structural organisation of the pigeon retina. Progress in Retinal Research 1982; 1: 197–226.
Ulrich DJ, Blough PM, Blough DS . The pigeon's distant visual acuity as a function of viewing angle. Vision Res 1982; 22: 429–31.
Catania AC . On the visual acuity of the pigeon. J Exp Anal Behav 1964; 7: 361–6.
Millodot M, and Blough P . The refractive state of the pigeon eye. Vision Res 1971; 11: 1019–22.
Nye PW . On the functional differences between frontal and lateral visual fields of the pigeon. Vision Res 1973; 13: 559–74.
Erichsen JT . ‘How Birds look at Objects’ D.Phil. Thesis, Oxford University, 1979.
Glickstein M, and Millodot M . Retinoscopy and eye size. Science, NY 1970; 168: 605–6.
Westheimer G . The Maxwellian View. Vision Res 1966; 6: 669–82.
Emsley HH . Visual Optics. Vol 1, London, Hatton Press, 1952.
Hodos W, Erichsen JT, Bessette BB, Phillips SJ . Head orientation in pigeons: postural, locomotor and visual determinants. Neurosci Abstr 1984; 10: 397.
Martin GR, and Young SR . The retinal binocular field of the pigeon (Columba livia; English Racing Homer). Vision Res 1983; 23: 911–15.
Martinoya G, Rey J, Bloch S . Limits of the pigeon's binocular field and direction for best binocular viewing. Vision Res 1981; 21: 1197–200.
Cooper ML and Pettigrew JD . A neurophysiological determination of the vertical horopter in the cat and owl. J Comp Neurol 1979; 184: 1–26.
Hodos W, and Erichsen JT . Lower-field myopia in birds: an adaptation that keeps the ground in focus. 1988 (personal communication).
Yinon U, Rose L, Shapiro A . Myopia in the eye of developing chicks following monocular and binocular lid closure. Vision Res 1980; 20: 137–41.
Yinon U, Koslowe KC, Lobel D, Landshman N, Barishak YR . Lid suture myopia in developing chicks: optical and structural considerations. Curr Eye Res 1983; 2: 877–82.
Jensen LS, and Matson WE . Enlargement of avian eye by subjecting chicks to continuous incandescent illumination. Science 1957; 125: 741.
Lauber JK . Review: Light induced avian glaucoma as an animal model for human primary glaucoma. J Ocular Pharmacol 1987; 3: 77–100.
Yinon U, and Koslowe KC . Hypermetropia in dark reared chicks and the effect of lid suture. Vision Res 1986; 26: 999–1005.
Gottleib MD, Fugate-Wentzek LA, Wallman J . Different visual deprivations produce different ametropias and different eye shapes. Invest Ophthalmol Vis Sci 1987; 28: 1225–35.
Wallman J, Turkei J, Trachtman J . Extreme myopia produced by modest change in early visual experience. Science 1978; 201: 1249–51.
Hodos W, and Kuenzel WJ . Retinal image degradation produces ocular enlargement in chicks. Invest Ophthalmol Vis Sci 1984; 25: 652–9.
Pickett-Seltner RL, Weerheim J, Sivak JG, Pasternak J . Experimentally induced myopia does not affect post-hatching development of the chick lens. Vision Res 1987; 27: 1779–82.
Pickett-Seltner RL, Sivak JG, Pasternak JJ . Experimentally induced myopia in chicks: morphometric and biochemical analysis during the first 14 days after hatching. Vision Res 1988; 28: 323–8.
Hirsch M . The relationship between measles and myopia. Am J Optom Arch Amer Acad Optom 1957; 34: 289.
Hodos W, Revzin AM, and Kuenzel WJ . Thermal gradients in the chick eye: a contributing factor in experimental myopia. Invest Ophthalmol Vis Sci 1987; 28: 1859–66.
Wallman J, Gottleib MD, Rajaram V, Fugate-Wentzek LA . Local retinal regions control local eye growth and myopia. Science NY 1987; 237: 73–7.
Troilo D, Gottleib MD, Wallman J . Visual deprivation causes myopia in chicks with optic nerve section. Curr Eye Res 1987; 6: 993–9.
Schaeffel F, Howland HC, Farkas L . Natural accommodation in the growing chicken. Vision Res 1986; 26: 1977–93.
Schaeffel F, Glasser A, Howland HC . Accommodation, refractive error and eye growth in chickens. Vision Res 1988; 28: 639–57.
Schaeffel F, Troilo D, Wallman J, Howland HC . Chickens without accommodation become myopic or hyperopic from wearing lenses. Invest Ophthalmol Vis Sci 1988; 29: (suppl) 445.
Hodos W, Bessette BB, Wilkinson JL, Kuenzel WJ . Frontal field lenses produce equatorial enlargement in chick eyes. Invest Ophthalmol Vis Sci 1988; 29: (suppl) 33.
Smith EL, Maguire GW, and Watson JT . Axial lengths and refractive errors in kittens reared with optically induced anisometria. Invest Ophthalmol Vis Sci 1980; 19: 1250–5.
Smith EL, Harwerth RS, Crawford MLJ . Spatial contrast sensitivity deficits in monkeys produced by optically induced anisometria. Invest Ophthalmol Vis Sci 1985; 26: 330–42.
Crewther SG, Nathan J, Kiely PM, Brennan N, Crewther DP . Axial hypermetropia induced in primates. Invest Ophthalmol Vis Sci 1986; 27: (suppl) 202.
Wilson JR, Fernandes A, Chandler CV, Tigges M, Boothe RG, Gammon JA . Abnormal development of the axial length of aphakic monkey eyes. Invest Ophthalmol Vis Sci 1987; 28: 2096–99.
Wallman J, and Adams JI . Developmental aspects of experimental myopia in chicks: susceptibility, recovery and relation to emmetropization. Vision Res 1987; 27: 1139–63.
Troilo D, and Wallman J . Experimental emmetropization in chicks. Invest Ophthalmol Vis Sci 1988; 29: (suppl) 76.
Groschke AC, Anderson JO, Briggs GM . Peculiar enlargement of eyeballs in chicks caused by feeding a high level of glycine. Proc Soc Exp Biol Med 1948; 69: 488.
Heimsen RJ, Gaasterland DE, Rubin M . Induction of buphthalmos in chicks fed an excess of glycine. Invest Ophthalmol 1973; 12: 348–53.
Wildsoet CF, and Pettigrew JD . Kainic acid induced eye enlargement in chickens: differential effects on anterior and posterior segments. Invest Ophthalmol Vis Sci 1988; 29: 311–19.
Smith EL, Fox DA, Duncan GC . Refractive error changes in kitten eyes produced by chronic on-channel blockade. Invest Ophthalmol Vis Sci 1985; 26: (suppl) 331.
Lin T, Stone RA, Laties AM, Iuvone PM . Altered dopamine metabolism and form deprivation myopia. Invest Ophthalmol Vis Sci 1988; 29: (suppl) 33.
Stone RA, Laties AM, Raviola E, Wiesel T . Increase in retinal vasoactive intestinal polypeptide after eyelid fusion in primates. Proc Natl Acad Sci 1988; 85: 257–60.
Butler JM, Ruskell GL, Cole DF, Unger WG, Zhang SQ, Blank MA, McGregor GP, Bloom SR . Effects of VIIth (facial) nerve degeneration on vasoactive intestinal polypeptide and substance P levels in ocular and orbital tissues of the rabbit. Exp Eye Res 1984; 39: 523–32.
Eriksen EF, and Larsson LI . Neuropeptides in the retina: evidence for differential topical localisation. Peptides 1981; 2: 153–7.
Lankford KL, DeMello FG, and Klein WL . D1-type dopamine receptors inhibit growth cone motility in cultured retina neurons: Evidence that neurotransmitters act as morphogenetic growth regulators in the developing central nervous system. Proc Natl Acad Sci 1988; 85: 2839–43.
Lloyd RIL . Birth injuries of the cornea and allied conditions. Am J Ophthalmol 1938; 21: 359–64.
Angell K, Robb RM, Berson FG . Visual prognosis in patients with ruptures in Descemet's membrane due to forceps injuries. Arch Ophthalmol 1981; 99: 2137–9.
Muramatsu T, Sato A, Tokoro T . Influence of corneal opacities on development of myopia. Folia Ophthal Jap 1982; 33: 1084–8.
Johnson CA, Post RB, Chalupa LM, Lee TJ . Monocular deprivation in humans: a study of identical twins. Invest Ophthalmol Vis Sci 1982; 23: 135–8.
von Noorden GK, and Lewis RA . Ocular axial length in unilateral congenital cataracts and blepharoptosis. Invest Ophthalmol Vis Sci 1987; 28: 750–2.
Robb RM . Refractive errors associated with hemangiomas of the eyelids and orbit in infancy. Am J Ophthalmol 1977; 83: 52–8.
Hoyt CS, Stone RD, Fromer C, Billson FA . Monocular axial myopia associated with neonatal eyelid closure in human infants. Am J Ophthalmol 1981; 91: 197–200.
Rabin J, Van Sluyters RC, Malach R . Emmetropisation: a vision dependent phenomenon. Invest Ophthalmol Vis Sci 1981; 20: 561–4.
Wallman J, Adams JI, Trachtman JN . The eyes of young chickens grow toward emmetropia. Invest Ophthalmol Vis Sci 1981; 20: 557–61.
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Holden, A., Hodos, W., Hayes, B. et al. Myopia: Induced, normal and clinical. Eye 2 (Suppl 1), S242–S256 (1988). https://doi.org/10.1038/eye.1988.148
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DOI: https://doi.org/10.1038/eye.1988.148
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